Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2666543 | 0.91 | OPRM1 (0.33) | PORCN | |
| SCHEMBL5457175 | 0.82 | CACNA1H (0.39) | RAB9ANPC1HTTLMNAKMT2A | |
| SCHEMBL2666710 | 0.75 | MAPK1 (0.40) | RAB9ANPC1KMT2AMEN1TSHR | |
| SCHEMBL2656449 | 0.75 | TSHR (0.38) | RAB9ANPC1KMT2AMEN1TSHR | |
| SCHEMBL2666597 | 0.73 | CACNA1H (0.38) | HTTKMT2ASMN1; SMN2 | |
| SCHEMBL2643471 | 0.73 | MAPK10 (0.40) | SMN1; SMN2GAA | |
| SCHEMBL2666860 | 0.72 | PORCN (0.35) | PORCNGCK | |
| SCHEMBL2666861 | 0.72 | OPRM1 (0.32) | PORCN | |
| SCHEMBL2666711 | 0.72 | ALDH1A1 (0.45) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2643472 | 0.72 | RAB9A (0.45) | RAB9ANPC1HTTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053765-A2 | SUBSTITUTED CYCLOALKYLPYRROLONES AS ALLOSTERIC MODULATORS OF GLUCOKINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-10 | — | — | WO | disclosed |