Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7285807 | 0.78 | KDM4E (0.56) | ALDH1A1KDM4EHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL16536963 | 0.74 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL15099945 | 0.73 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL16536117 | 0.73 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL16543633 | 0.73 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL16536004 | 0.73 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDSMN1; SMN2NPSR1 | |
| Hydrochloric Acid SCHEMBL16536006 | 0.72 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL29842568 | 0.71 | KDM4E (0.40) | ALDH1A1KDM4EHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL19610996 | 0.70 | KDM4E (0.48) | ALDH1A1KDM4EMAPTL3MBTL1KMT2A | |
| SCHEMBL6222317 | 0.70 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230382910-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED | 2023-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230382910-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | TRPV1, SCN3A, KCNN3 | ALDH1A1 1762/4885KDM4E 4346/4885HPGD 546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.