Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26689195 | 0.92 | ALDH1A1 (0.39) | NOTUMSMN1; SMN2HSD17B3ALDH1A1GAA | |
| SCHEMBL30686749 | 0.92 | ALDH1A1 (0.39) | NOTUMSMN1; SMN2HSD17B3ALDH1A1GAA | |
| Iodide SCHEMBL26677808 | 0.91 | ALDH1A1 (0.38) | NOTUMSMN1; SMN2HSD17B3ALDH1A1GAA | |
| Bicarbonate SCHEMBL22393229 | 0.75 | ALOX15 (0.40) | GAATSHRKMT2AHPGD | |
| SCHEMBL29425026 | 0.74 | LMNA (0.44) | GAATSHRKDM4EHPGDHSD17B10 | |
| SCHEMBL26677809 | 0.71 | SMN1; SMN2 (0.35) | NOTUMSMN1; SMN2HSD17B3ALDH1A1GAA | |
| SCHEMBL23366510 | 0.70 | KDM4E (0.35) | HSD17B3ALDH1A1MAPTMEN1TSHR | |
| SCHEMBL15893966 | 0.69 | CNR2 (0.47) | NOTUMHSD17B3ALDH1A1DPP7CNR2 | |
| SCHEMBL19454489 | 0.68 | HSD17B10 (0.37) | NOTUMALDH1A1MAPTHSD17B10CYP2C19 | |
| SCHEMBL22843391 | 0.67 | NOTUM (0.50) | NOTUMSMN1; SMN2ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230381812-A1 | Method of Selective Deposition of Small Molecules on Metal Surfaces | UNIVERSITE LAVAL (CA) | 2023-11-30 | — | — | US | disclosed |
| WO-2023201437-A1 | METHOD OF SELECTIVE DEPOSITION OF SMALL MOLECULES ON METAL SURFACES | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2023-10-26 | — | — | WO | disclosed |