Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | GCK | P35557 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9070971 | 0.90 | GCK (0.53) | SMN1; SMN2BRD4MAPTRAB9AMAPK1 | |
| SCHEMBL9070795 | 0.90 | GCK (0.47) | SMN1; SMN2BRD4MAPTRAB9AMAPK1 | |
| SCHEMBL2667643 | 0.87 | RAB9A (0.49) | SMN1; SMN2MAPTRAB9AMAPK1NPC1 | |
| SCHEMBL2667945 | 0.87 | RAB9A (0.51) | SMN1; SMN2BRD4MAPTRAB9AMAPK1 | |
| SCHEMBL2667957 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2BRD4MAPTRAB9AMAPK1 | |
| SCHEMBL9070870 | 0.84 | RAB9A (0.53) | SMN1; SMN2BRD4MAPTRAB9AMAPK1 | |
| SCHEMBL2667947 | 0.82 | CASP3 (0.56) | SMN1; SMN2MAPTRAB9ANPC1LMNA | |
| SCHEMBL9070898 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2BRD4MAPTRAB9AMAPK1 | |
| SCHEMBL2667755 | 0.81 | NPC1 (0.46) | SMN1; SMN2RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL2667940 | 0.81 | GCK (0.68) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083553-A1 | AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS | RHEOSCIENCE A/S (DK) | 2009-07-09 | — | — | WO | disclosed |