Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyrophosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 3/20 | 0.59 |
| ▸ | FDPS | P14324 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.35 |
| ▸ | BTN3A1 | O00481 | 3/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrophosphoric Acid SCHEMBL63982 | 1.00 | BLM (0.59) | BLMFDPSTDP1ALDH1A1TSHR | |
| Triphosphate SCHEMBL27463634 | 0.89 | BLM (0.45) | BLMFDPSTDP1ALDH1A1TSHR | |
| Pyrophosphoric Acid SCHEMBL2671881 | 0.88 | BLM (0.67) | BLMFDPSTDP1ALDH1A1TSHR | |
| Pyrophosphoric Acid SCHEMBL8837385 | 0.84 | FDPS (0.71) | BLMFDPSTDP1TSHRPPARD | |
| Pyrophosphoric Acid SCHEMBL2575783 | 0.84 | FDPS (0.71) | BLMFDPSTDP1TSHRPPARD | |
| Pyrophosphoric Acid SCHEMBL17311814 | 0.82 | FDPS (0.59) | BLMFDPSTDP1ALDH1A1TSHR | |
| Pyrophosphoric Acid SCHEMBL17311822 | 0.82 | FDPS (0.59) | BLMFDPSTDP1ALDH1A1TSHR | |
| Monoethanolamine SCHEMBL5455777 | 0.81 | BLM (0.38) | BLMFDPSTDP1ALDH1A1TSHR | |
| Phosphoric Acid SCHEMBL64139 | 0.81 | ALDH1A1 (0.61) | BLMFDPSALDH1A1TSHRLMNA | |
| Phosphoric Acid SCHEMBL63996 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230381223-A1 | ORAL PYROPHOSPHATE FOR USE IN REDUCING CALCIFICATION | PXE INTERNATIONAL, INC. | 2023-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230381223-A1 | ORAL PYROPHOSPHATE FOR USE IN REDUCING CALCIFICATION | ALPI, ALPP, PHOSPHO1 | BLM 2198/4885FDPS 2061/4885TDP1 2436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.