Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SIK1 | P57059 | 2/20 | 0.39 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.39 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2669747 | 0.81 | THRB (0.47) | THRBSIK1SIK2SIK3HPGD | |
| SCHEMBL1616888 | 0.80 | FGFR1 (0.46) | SIK1SIK2SIK3HPGDFGFR1 | |
| SCHEMBL2659103 | 0.79 | FGFR1 (0.43) | THRBHPGDCYP1A2CYP2C9MAPK1 | |
| SCHEMBL2657582 | 0.79 | THRB (0.39) | THRBHPGDCYP1A2CYP2C9MAPK1 | |
| SCHEMBL1616645 | 0.79 | FGFR1 (0.43) | THRBHPGDFGFR1ALDH1A1GABRA1 | |
| SCHEMBL1616674 | 0.79 | FGFR1 (0.43) | THRBHPGDFGFR1ALDH1A1GABRA1 | |
| SCHEMBL2657860 | 0.77 | GABRA1 (0.46) | THRBHPGDCYP1A2CYP2C9MAPK1 | |
| SCHEMBL2658314 | 0.77 | SIK1 (0.40) | THRBSIK1SIK2SIK3HPGD | |
| SCHEMBL2658684 | 0.77 | FGFR1 (0.39) | THRBSIK1SIK2SIK3HPGD | |
| SCHEMBL2657689 | 0.77 | SIK1 (0.40) | THRBSIK1SIK2SIK3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010055125-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2010-05-20 | — | — | WO | disclosed |