Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | IDH1 | O75874 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.49 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26697287 | 0.81 | RAB9A (0.65) | RAB9AMAPTSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL26697246 | 0.81 | KMT2A (0.56) | RAB9AMAPTSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL21750964 | 0.81 | KDR (0.57) | MAPTTSHRMEN1KMT2AGAA | |
| SCHEMBL26697279 | 0.78 | NPC1 (0.53) | RAB9AMAPTSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL12824892 | 0.76 | RAB9A (0.78) | RAB9AMAPTSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL26697211 | 0.76 | HTT (0.65) | RAB9AMAPTSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL15074664 | 0.76 | LMNA (0.66) | RAB9AMAPTSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL29757932 | 0.75 | RAB9A (0.56) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL21750906 | 0.75 | RAB9A (0.56) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL12218116 | 0.75 | MEN1 (0.68) | RAB9AMAPTSMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114920703-B | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2024-01-09 | — | — | CN | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| CN-114920703-A | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2022-08-19 | — | — | CN | disclosed |