Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 8/20 | 0.62 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.58 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.55 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5640255 | 0.86 | KMT2A (0.78) | KMT2APOLBMEN1MDM2SMARCA2 | |
| SCHEMBL21750979 | 0.84 | MAOA (0.61) | KMT2APOLBMEN1MAPTHTT | |
| SCHEMBL29757943 | 0.84 | MAOA (0.61) | KMT2APOLBMEN1MAPTHTT | |
| SCHEMBL26697246 | 0.82 | KMT2A (0.56) | KMT2APOLBMEN1MAPTHTT | |
| SCHEMBL21750906 | 0.82 | RAB9A (0.56) | KMT2APOLBMEN1HTTGRIK1 | |
| SCHEMBL29757932 | 0.82 | RAB9A (0.56) | KMT2APOLBMEN1HTTGRIK1 | |
| SCHEMBL26697260 | 0.81 | CA12 (0.64) | KMT2AMEN1MAPTHTTGRIK1 | |
| SCHEMBL26697200 | 0.79 | GRIK1 (0.58) | KMT2APOLBMEN1MAPTLMNA | |
| SCHEMBL14514332 | 0.79 | KMT2A (0.64) | KMT2APOLBMEN1MAPTHTT | |
| SCHEMBL195117 | 0.76 | KMT2A (0.67) | KMT2APOLBMEN1MDM2SMARCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114920703-B | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2024-01-09 | — | — | CN | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| CN-114920703-A | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2022-08-19 | — | — | CN | disclosed |