Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.58 |
| ▸ | CNR1 | P21554 | 7/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21750979 | 0.91 | MAOA (0.61) | GRIK1MEN1MAPTKMT2ANPC1 | |
| SCHEMBL29757943 | 0.91 | MAOA (0.61) | GRIK1MEN1MAPTKMT2ANPC1 | |
| SCHEMBL29757932 | 0.82 | RAB9A (0.56) | GRIK1CNR1MEN1KMT2ANPC1 | |
| SCHEMBL26697246 | 0.82 | KMT2A (0.56) | GRIK1MEN1MAPTKMT2ANPC1 | |
| SCHEMBL21750906 | 0.82 | RAB9A (0.56) | GRIK1CNR1MEN1KMT2ANPC1 | |
| SCHEMBL5594862 | 0.80 | CXCR2 (0.62) | GRIK1CNR1MEN1MAPTKMT2A | |
| SCHEMBL26697254 | 0.79 | KMT2A (0.72) | GRIK1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL3668804 | 0.79 | CNR1 (0.61) | GRIK1CNR1MEN1MAPTKMT2A | |
| SCHEMBL26697260 | 0.79 | CA12 (0.64) | GRIK1MEN1MAPTKMT2ARAB9A | |
| SCHEMBL420364 | 0.79 | GRIK1 (0.80) | GRIK1CNR1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114920703-B | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2024-01-09 | — | — | CN | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| CN-114920703-A | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2022-08-19 | — | — | CN | disclosed |