Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | CCKAR | P32238 | 1/20 | 0.32 |
| ▸ | GCG | P01275 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.31 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.31 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2669847 | 0.87 | NAMPT (0.36) | NAMPTGCGHDAC6PIK3CBHDAC3 | |
| SCHEMBL2669769 | 0.86 | NAMPT (0.36) | NAMPTGCGPTGDR2HDAC6PIK3CB | |
| SCHEMBL2669810 | 0.85 | NAMPT (0.34) | NAMPTPIK3CB | |
| SCHEMBL2669784 | 0.82 | NAMPT (0.33) | NAMPTABCB11CYP3A4ADRA2BOPRD1 | |
| SCHEMBL13069831 | 0.82 | NPC1 (0.33) | CCKARLTB4R | |
| SCHEMBL2669939 | 0.82 | NPC1 (0.39) | ABCB11 | |
| SCHEMBL3402059 | 0.80 | NAMPT (0.38) | NAMPTGCGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL2669959 | 0.80 | SRC (0.33) | NAMPTCCKARP2RY12 | |
| SCHEMBL2669941 | 0.78 | TP53 (0.36) | NAMPTPIK3CBHDAC3HDAC1 | |
| SCHEMBL723029 | 0.77 | NAMPT (0.35) | NAMPTPTGDR2PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009110520-A1 | HETEROCYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2009-09-11 | — | — | WO | disclosed |