Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2669769 | 0.91 | NAMPT (0.36) | TP53MEN1KMT2ATSHRHTT | |
| SCHEMBL2669810 | 0.90 | NAMPT (0.34) | TP53MEN1KMT2ATSHRHTT | |
| SCHEMBL2669811 | 0.90 | TP53 (0.34) | TP53MEN1KMT2ATSHRHTT | |
| SCHEMBL2669956 | 0.88 | MAOB (0.35) | TP53MEN1KMT2ANAMPTMAPT | |
| SCHEMBL2669820 | 0.82 | FAAH (0.35) | NAMPT | |
| SCHEMBL2669895 | 0.81 | ESR1 (0.42) | TP53MEN1KMT2ATSHRHTT | |
| SCHEMBL2669847 | 0.81 | NAMPT (0.36) | NAMPTBRD4PIK3CBHDAC3HDAC1 | |
| SCHEMBL9070790 | 0.81 | NAMPT (0.34) | TP53MEN1KMT2ATSHRHTT | |
| SCHEMBL13069228 | 0.80 | TP53 (0.34) | TP53MEN1KMT2ATSHRHTT | |
| SCHEMBL2669991 | 0.80 | NAMPT (0.40) | KMT2ANAMPTBRD4MAPTPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009110520-A1 | HETEROCYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2009-09-11 | — | — | WO | disclosed |