Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Biguanide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 2/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biguanide SCHEMBL9449438 | 0.97 | KDM4E (0.46) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Biguanide SCHEMBL27327619 | 0.90 | KDM4E (0.46) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Biguanide SCHEMBL9665553 | 0.90 | KDM4E (0.46) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Sulfuric Acid SCHEMBL292733 | 0.85 | BLM (0.42) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Sulfuric Acid SCHEMBL9576365 | 0.83 | BLM (0.40) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Sulfuric Acid SCHEMBL9449436 | 0.83 | BLM (0.40) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Biguanide SCHEMBL18255803 | 0.82 | MAPK1 (0.31) | — | |
| Biguanide SCHEMBL8039 | 0.82 | — | — | |
| Hydroxyguanidine SCHEMBL961746 | 0.80 | BLM (0.48) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL728583 | 0.80 | KDM4E (0.48) | KDM4EBLMCYP2D6CYP2C19NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119280450-A | Medical fabric dressing with long-acting disinfection and sterilization functions and preparation method thereof | 孙国明 | 2025-01-10 | — | — | CN | claimed |
| CN-118844836-A | Long-acting disinfection and sterilization wet (towel) paper | 孙国明 | 2024-10-29 | — | — | CN | claimed |
| CN-118844448-A | Preparation method of long-acting antibacterial liquid | 孙国明 | 2024-10-29 | — | — | CN | claimed |
| CN-117084263-A | Oilfield reinjection water composite bactericide and preparation method thereof | 郑州德融科技有限公司 | 2023-11-21 | — | — | CN | claimed |
| CN-113003677-B | Efficient environment-friendly bactericide for oilfield produced water and preparation method thereof | 天津大港油田滨港集团博弘石油化工有限公司 | 2023-04-04 | — | — | CN | claimed |
| CN-114656768-A | High-temperature-resistant brominated flame-retardant plastic and preparation method thereof | 湖南登科材料科技有限公司 | 2022-06-24 | — | — | CN | claimed |
| US-20180134672-A1 | ANTIMICROBIAL COMPOUNDS, METHODS OF MAKING THE SAME AND ARTICLES COMPRISING THEM | MEDICAL TECHNOLOGY RESEARCH INC | 2018-05-17 | — | — | US | claimed |
| CN-107207448-A | Antimicrobial compounds, methods of making the same, and articles comprising the same | 医学科技研究公司 | 2017-09-26 | — | — | CN | claimed |
| EP-3201182-A2 | ANTIMICROBIAL COMPOUNDS, METHODS OF MAKING THE SAME AND ARTICLES COMPRISING THEM | Medical Technology Research Inc. (US) | 2017-08-09 | — | — | EP | claimed |
| WO-2016054284-A2 | ANTIMICROBIAL COMPOUNDS, METHODS OF MAKING THE SAME AND ARTICLES COMPRISING THEM | MEDICAL TECHNOLOGY RESEARCH INC (US) | 2016-04-07 | — | — | WO | claimed |
| CN-119280450-A | Medical fabric dressing with long-acting disinfection and sterilization functions and preparation method thereof | 孙国明 | 2025-01-10 | — | — | CN | disclosed |
| CN-118844836-A | Long-acting disinfection and sterilization wet (towel) paper | 孙国明 | 2024-10-29 | — | — | CN | disclosed |
| CN-118844448-A | Preparation method of long-acting antibacterial liquid | 孙国明 | 2024-10-29 | — | — | CN | disclosed |
| CN-118240387-A | Mildew-proof sponge material and preparation method thereof | 扬州中天海绵有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-117084263-A | Oilfield reinjection water composite bactericide and preparation method thereof | 郑州德融科技有限公司 | 2023-11-21 | — | — | CN | disclosed |
| US-4559409-A | Process for manufacturing guanylurea sulfamate | SKW TROSTBERG (DE) | 1985-12-17 | — | — | US | disclosed |
| US-4405806-A | Bromine-containing 2,4-diaminotriazines | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 1983-09-20 | — | — | US | disclosed |
| US-4352930-A | Bromine-containing 2,4-diaminotriazines | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 1982-10-05 | — | — | US | disclosed |
| US-4055720-A | FIREPROOFING, WRINKLE RESISTANCE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 1977-10-25 | — | — | US | disclosed |
| US-3966727-A | Manufacture of phthalo-bis-guanamines | BASF AKTIENGESELLSCHAFT (DT) | 1976-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134672-A1 | ANTIMICROBIAL COMPOUNDS, METHODS OF MAKING THE SAME AND ARTICLES COMPRISING THEM | GSDMD, TIAL1, AAAS | KDM4E 3823/4885BLM 1179/4885CYP2D6 2410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.