Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Pimagedine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.39 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 2/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimagedine SCHEMBL439903 | 1.00 | KDM4E (0.48) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL28939705 | 0.97 | KDM4E (0.46) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL9702626 | 0.97 | KDM4E (0.46) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL4259785 | 0.90 | KDM4E (0.46) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL4821332 | 0.90 | KDM4E (0.46) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL9797617 | 0.90 | TSHR (0.50) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL27731082 | 0.89 | ALDH1A1 (0.53) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL30862143 | 0.83 | LMNA (0.43) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL30862137 | 0.83 | CYP2C19 (0.40) | KDM4EBLMCYP2D6CYP2C19NPSR1 | |
| Pimagedine SCHEMBL7763659 | 0.82 | ALDH1A1 (0.43) | TSHRCYP1A2NFKB1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1493453-B1 | Absorbent comprising coated super-absorbent polymer particles | PROCTER & GAMBLE (US) | 2010-12-22 | — | — | EP | claimed |
| US-7311968-B2 | Absorbent structures comprising coated super-absorbent polymer particles | THE PROCTER & GAMBLE COMPANY (US) | 2007-12-25 | — | — | US | claimed |
| WO-1992004302-A1 | GUANIDINE AS A NITROGEN FERTILIZER | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 1992-03-19 | — | — | WO | claimed |
| CN-111912838-B | BNP chemiluminescence detection kit and application thereof | 宁波瑞源生物科技有限公司 | 2023-05-12 | — | — | CN | disclosed |
| CN-112512498-A | Hair cosmetic | 花王株式会社 | 2021-03-16 | — | — | CN | disclosed |
| US-10633332-B2 | Guanidine compounds for removal of oxyanions from aqueous solutions and for carbon dioxide capture | UT-BATTELLE, LLC (US) | 2020-04-28 | — | — | US | disclosed |
| US-20190010118-A1 | GUANIDINE COMPOUNDS FOR REMOVAL OF OXYANIONS FROM AQUEOUS SOLUTIONS AND FOR CARBON DIOXIDE CAPTURE | UT-BATTELLE, LLC (US) | 2019-01-10 | — | — | US | disclosed |
| US-20180134655-A1 | GUANIDINE COMPOUNDS FOR REMOVAL OF OXYANIONS FROM AQUEOUS SOLUTIONS AND FOR CARBON DIOXIDE CAPTURE | U.S. DEPARTMENT OF ENERGY | 2018-05-17 | — | — | US | disclosed |
| US-8791320-B2 | Absorbent structures comprising coated super-absorbent polymer particles | THE PROCTER & GAMBLE COMPANY (US) | 2014-07-29 | — | — | US | disclosed |
| EP-1654012-B1 | WATER-SWELLABLE MATERIAL COMPRISING COATED WATER-SWELLABLE POLYMER PARTICLES | BASF SE (DE) | 2013-04-24 | — | — | EP | disclosed |
| US-8137746-B2 | Elastomers | THE PROCTER & GAMBLE COMPANY (US) | 2012-03-20 | — | — | US | disclosed |
| US-20050014933-A1 | Process for renaturation of recombinant, disulfide containing proteins at high protein concentrations in the presence of amines | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2005-01-20 | — | — | US | disclosed |
| US-20050003191-A1 | Absorbent structures comprising coated super-absorbent polymer particles | THE PROCTER & GAMBLE COMPANY (US) | 2005-01-06 | — | — | US | disclosed |
| EP-1493453-A1 | Absorbent comprising coated super-absorbent polymer particles | The Procter & Gamble Company (US) | 2005-01-05 | — | — | EP | disclosed |
| EP-1453858-A1 | PROCESS FOR RENATURATION OF RECOMBINANT, DISULFIDE CONTAINING PROTEINS AT HIGH PROTEIN CONCENTRATIONS IN THE PRESENCE OF AMINES | Bayer HealthCare AG (DE) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003044055-A1 | PROCESS FOR RENATURATION OF RECOMBINANT, DISULFIDE CONTAINING PROTEINS AT HIGH PROTEIN CONCENTRATIONS IN THE PRESENCE OF AMINES | BAYER HEALTHCARE AG (DE) | 2003-05-30 | — | — | WO | disclosed |
| EP-1314739-A1 | Process for renaturation of recombinant, disulfide containing proteins at high protein concentrations in the presence of amines | BAYER AG (DE) | 2003-05-28 | — | — | EP | disclosed |
| WO-1992004302-A1 | GUANIDINE AS A NITROGEN FERTILIZER | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 1992-03-19 | — | — | WO | disclosed |
| WO-1992004302-A1 | GUANIDINE AS A NITROGEN FERTILIZER | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 1992-03-19 | — | — | WO | disclosed |
| US-4479917-A | Use of aminoguanidine compounds as oxygen-scavenging and corrosion-inhibiting agents | OLIN CORPORATION (US) | 1984-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014933-A1 | Process for renaturation of recombinant, disulfide containing proteins at high protein concentrations in the presence of amines | SPR, P4HB, WIZ | MAOA 2539/4885MAOB 1796/4885KDM4E 4448/4885 |
| US-20190010118-A1 | GUANIDINE COMPOUNDS FOR REMOVAL OF OXYANIONS FROM AQUEOUS SOLUTIONS AND FOR CARBON DIOXIDE CAPTURE | GUCY1A1, GUCY1A2, GUCY1B1 | MAOA 431/4885MAOB 438/4885KDM4E 1102/4885 |
| US-10633332-B2 | Guanidine compounds for removal of oxyanions from aqueous solutions and for carbon dioxide capture | GUCY1A1, GUCY1A2, GUCY1B1 | MAOA 431/4885MAOB 438/4885KDM4E 1102/4885 |
| US-20180134655-A1 | GUANIDINE COMPOUNDS FOR REMOVAL OF OXYANIONS FROM AQUEOUS SOLUTIONS AND FOR CARBON DIOXIDE CAPTURE | GUCY1A1, GUCY1A2, GUCY1B1 | MAOA 431/4885MAOB 438/4885KDM4E 1102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.