Sugi Predict

Sugi Predict / Compounds / SCHEMBL2671108

SCHEMBL2671108

SCHEMBL2671108

CCOC(=O)c1cnn(C2CCC2)c1Br

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.48
▸ ALDH1A1 P00352 6/20 0.44
▸ RAB9A P51151 3/20 0.44
▸ NPSR1 Q6W5P4 2/20 0.44
▸ NPC1 O15118 2/20 0.44
▸ CYP1A2 P05177 1/20 0.44
▸ CYP3A4 P08684 1/20 0.44
▸ CYP2D6 P10635 1/20 0.44
▸ CYP2C9 P11712 1/20 0.44
▸ CYP2C19 P33261 1/20 0.44
▸ OPRK1 P41145 4/20 0.44
▸ PDE4B Q07343 2/20 0.42
▸ MAPK1 P28482 1/20 0.42
▸ TSHR P16473 2/20 0.41
▸ MAPT P10636 1/20 0.41
▸ KDM4E B2RXH2 2/20 0.41
▸ HSD17B10 Q99714 1/20 0.41
▸ HPGD P15428 1/20 0.40
▸ AKR1C3 P42330 1/20 0.40
▸ AKR1C2 P52895 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23273663 0.94 LMNA (0.47) LMNAALDH1A1RAB9ANPSR1NPC1
SCHEMBL23289754 0.88 PDE4B (0.48) LMNAPDE4B
SCHEMBL1063097 0.87 LMNA (0.42) LMNAALDH1A1RAB9ANPSR1NPC1
SCHEMBL23289755 0.85 LMNA (0.44) LMNAALDH1A1RAB9ANPC1OPRK1
SCHEMBL30984194 0.85 LMNA (0.49) LMNAALDH1A1RAB9ANPSR1NPC1
SCHEMBL1407209 0.84 LMNA (0.48) LMNAALDH1A1RAB9ANPSR1NPC1
SCHEMBL13310664 0.84 LMNA (0.48) LMNAALDH1A1RAB9ANPSR1NPC1
SCHEMBL1407590 0.84 LMNA (0.60) LMNAALDH1A1RAB9ANPC1TSHR
SCHEMBL574443 0.83 LMNA (0.53) LMNAALDH1A1RAB9ANPSR1NPC1
SCHEMBL1061726 0.82 GPR119 (0.45) LMNAALDH1A1NPSR1TSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250382304-A1 HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS NUVALENT INC (US) 2025-12-18 — — US disclosed
US-12275742-B2 Heteroaromatic macrocyclic ether chemotherapeutic agents NUVALENT, INC. (US) 2025-04-15 — — US disclosed
US-11667649-B2 Heteroaromatic macrocyclic ether chemotherapeutic agents NUVALENT, INC. (US) 2023-06-06 — — US disclosed
US-11667649-B2 Heteroaromatic macrocyclic ether chemotherapeutic agents NUVALENT, INC. (US) 2023-06-06 — — US disclosed
US-11667649-B2 Heteroaromatic macrocyclic ether chemotherapeutic agents NUVALENT, INC. (US) 2023-06-06 — — US disclosed
CN-115916196-A Heteroaromatic macrocyclic ether chemotherapeutic agents 纽威伦特公司 2023-04-04 — — CN disclosed
EP-4146205-A1 HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS Nuvalent, Inc. (US) 2023-03-15 — — EP disclosed
US-20230076627-A1 HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS NUVALENT, INC. 2023-03-09 — — US disclosed
US-20230076627-A1 HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS NUVALENT, INC. 2023-03-09 — — US disclosed
US-20220340586-A9 HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS NUVALENT, INC. 2022-10-27 — — US disclosed
EP-2952514-A1 N1/N2-LACTAM ACETYL-COA CARBOXYLASE INHIBITORS Pfizer Inc (US) 2015-12-09 — — EP disclosed
US-9181252-B2 N1/N2-lactam acetyl-CoA carboxylase inhibitors PFIZER INC. (US) 2015-11-10 — — US disclosed
US-20150152109-A1 N1/N2-LACTAM ACETYL-COA CARBOXYLASE INHIBITORS PFIZER INC. (US) 2015-06-04 — — US disclosed
EP-2632925-B1 N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS PFIZER (US) 2015-05-27 — — EP disclosed
US-8993586-B2 N1/N2-lactam acetyl-CoA carboxylase inhibitors PFIZER INC. (US) 2015-03-31 — — US disclosed
US-20150025098-A1 N1/N2-LACTAM ACETYL-COA CARBOXYLASE INHIBITORS PFIZER INC. (US) 2015-01-22 — — US disclosed
US-8859773-B2 N1/N2-lactam acetyl-CoA carboxylase inhibitors PFIZER INC. (US) 2014-10-14 — — US disclosed
EP-2632925-A1 N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS Pfizer Inc (US) 2013-09-04 — — EP disclosed
US-20120108619-A1 N1/N2-LACTAM ACETYL-COA CARBOXYLASE INHIBITORS PFIZER INC 2012-05-03 — — US disclosed
WO-2012056372-A1 N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS PFIZER INC. (US) 2012-05-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150025098-A1 N1/N2-LACTAM ACETYL-COA CARBOXYLASE INHIBITORS ACACA, ACACB, COASY LMNA 1674/4885ALDH1A1 158/4885RAB9A 2413/4885
US-20150152109-A1 N1/N2-LACTAM ACETYL-COA CARBOXYLASE INHIBITORS ACACA, ACACB, COASY LMNA 1674/4885ALDH1A1 158/4885RAB9A 2413/4885
US-20120108619-A1 N1/N2-LACTAM ACETYL-COA CARBOXYLASE INHIBITORS ACACA, ACACB, COASY LMNA 1674/4885ALDH1A1 158/4885RAB9A 2413/4885
US-12275742-B2 Heteroaromatic macrocyclic ether chemotherapeutic agents CYP2C8, ABCB1, PAICS LMNA 2258/4885ALDH1A1 1313/4885RAB9A 3355/4885
US-11667649-B2 Heteroaromatic macrocyclic ether chemotherapeutic agents CYP2C8, ABCB1, PAICS LMNA 2258/4885ALDH1A1 1313/4885RAB9A 3355/4885
US-20230076627-A1 HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS CYP2C8, ABCB1, PAICS LMNA 2258/4885ALDH1A1 1313/4885RAB9A 3355/4885
US-20250382304-A1 HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS CYP2C8, ABCB1, PAICS LMNA 2258/4885ALDH1A1 1313/4885RAB9A 3355/4885
US-20220340586-A9 HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS ABCB1, CYP2C8, PAICS LMNA 1981/4885ALDH1A1 1361/4885RAB9A 3265/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.