Sugi Predict

Sugi Predict / Compounds / SCHEMBL2672107

SCHEMBL2672107

SCHEMBL2672107

COc1cc2cc(Br)ccc2cn1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.46
▸ GSK3A P49840 1/20 0.42
▸ CDK9 P50750 1/20 0.42
▸ CDK5 Q00535 1/20 0.42
▸ TAOK1 Q7L7X3 1/20 0.42
▸ CLK4 Q9HAZ1 1/20 0.42
▸ EGFR P00533 2/20 0.42
▸ THRB P10828 1/20 0.41
▸ GABRG2 P18507 2/20 0.39
▸ GABRB3 P28472 2/20 0.39
▸ GABRA5 P31644 2/20 0.39
▸ GABRA3 P34903 2/20 0.39
▸ KDM4E B2RXH2 2/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ CYP2A6 P11509 1/20 0.38
▸ IDO1 P14902 1/20 0.37
▸ TDO2 P48775 1/20 0.37
▸ GABRP O00591 1/20 0.36
▸ GABRD O14764 1/20 0.36
▸ GABRA1 P14867 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2671991 0.93 THRB (0.44) MAPTEGFRTHRBGABRG2GABRB3
SCHEMBL18318244 0.81 GABRA1 (0.42) GSK3ACDK9CDK5TAOK1CLK4
SCHEMBL14681553 0.77 GSK3A (0.39) MAPTGSK3ACDK9CDK5TAOK1
SCHEMBL30746959 0.76 KDM4E (0.57) MAPTGABRG2GABRB3GABRA5GABRA3
SCHEMBL1536432 0.76 KDM4E (0.57) MAPTGABRG2GABRB3GABRA5GABRA3
SCHEMBL28498490 0.75 ABL1 (0.40) MAPTGSK3ACDK9CDK5TAOK1
SCHEMBL6845001 0.75 CYP2A6 (0.57) MAPTGSK3ACDK9CDK5TAOK1
SCHEMBL23779278 0.74 KDM4E (0.59) EGFRGABRG2GABRB3GABRA5GABRA3
SCHEMBL18616685 0.74 MAPT (0.43) MAPTKDM4EPIK3CDPIK3CAPIK3CB
SCHEMBL15447975 0.74 NUDT1 (0.45) MAPTGSK3ACDK9CDK5TAOK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250257035-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2025-08-14 — — US disclosed
US-12098130-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2024-09-24 — — US disclosed
US-20230391723-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2023-12-07 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US disclosed
CN-107847765-B 1, 4-substituted piperidine derivatives 89生物有限公司 2021-05-04 — — CN disclosed
US-10851057-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2020-12-01 — — US disclosed
EP-3310441-B1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES 89BIO LTD (IL) 2020-07-29 — — EP disclosed
US-20190152913-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2019-05-23 — — US disclosed
US-10221135-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2019-03-05 — — US disclosed
US-20150025098-A1 N1/N2-LACTAM ACETYL-COA CARBOXYLASE INHIBITORS PFIZER INC. (US) 2015-01-22 — — US disclosed
US-8859773-B2 N1/N2-lactam acetyl-CoA carboxylase inhibitors PFIZER INC. (US) 2014-10-14 — — US disclosed
US-8859773-B2 N1/N2-lactam acetyl-CoA carboxylase inhibitors PFIZER INC. (US) 2014-10-14 — — US disclosed
US-8859773-B2 N1/N2-lactam acetyl-CoA carboxylase inhibitors PFIZER INC. (US) 2014-10-14 — — US disclosed
EP-2632925-A1 N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS Pfizer Inc (US) 2013-09-04 — — EP disclosed
US-20120108619-A1 N1/N2-LACTAM ACETYL-COA CARBOXYLASE INHIBITORS PFIZER INC 2012-05-03 — — US disclosed
US-20120108619-A1 N1/N2-LACTAM ACETYL-COA CARBOXYLASE INHIBITORS PFIZER INC 2012-05-03 — — US disclosed
US-20120108619-A1 N1/N2-LACTAM ACETYL-COA CARBOXYLASE INHIBITORS PFIZER INC 2012-05-03 — — US disclosed
WO-2012056372-A1 N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS PFIZER INC. (US) 2012-05-03 — — WO disclosed
WO-2012056372-A1 N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS PFIZER INC. (US) 2012-05-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150025098-A1 N1/N2-LACTAM ACETYL-COA CARBOXYLASE INHIBITORS ACACA, ACACB, COASY MAPT 1373/4885GSK3A 172/4885CDK9 2654/4885
US-20250257035-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A MAPT 3799/4885GSK3A 3415/4885CDK9 2428/4885
US-20190152913-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A MAPT 3799/4885GSK3A 3415/4885CDK9 2428/4885
US-20230391723-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A MAPT 3799/4885GSK3A 3415/4885CDK9 2428/4885
US-20210230116-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A MAPT 3799/4885GSK3A 3415/4885CDK9 2428/4885
US-20120108619-A1 N1/N2-LACTAM ACETYL-COA CARBOXYLASE INHIBITORS ACACA, ACACB, COASY MAPT 1373/4885GSK3A 172/4885CDK9 2654/4885
US-10221135-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A MAPT 3799/4885GSK3A 3415/4885CDK9 2428/4885
US-11702388-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A MAPT 3799/4885GSK3A 3415/4885CDK9 2428/4885
US-12098130-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A MAPT 3799/4885GSK3A 3415/4885CDK9 2428/4885
US-10851057-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A MAPT 3799/4885GSK3A 3415/4885CDK9 2428/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.