Sugi Predict

Sugi Predict / Compounds / SCHEMBL2673019

SCHEMBL2673019

SCHEMBL2673019

CC(c1ccccn1)N1CCNCC1

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ KCNA5 P22460 3/20 0.49
▸ PLD1 Q13393 1/20 0.49
▸ KCNE1 P15382 1/20 0.49
▸ SLC6A4 P31645 2/20 0.48
▸ CHRM2 P08172 1/20 0.46
▸ CHRM1 P11229 1/20 0.46
▸ MEN1 O00255 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ MAPT P10636 2/20 0.43
▸ HTR7 P34969 2/20 0.42
▸ ALDH1A1 P00352 2/20 0.41
▸ KDM4E B2RXH2 1/20 0.41
▸ CYP3A4 P08684 2/20 0.40
▸ CYP2D6 P10635 2/20 0.40
▸ LMNA P02545 1/20 0.40
▸ CYP2C19 P33261 1/20 0.40
▸ CYP1A2 P05177 1/20 0.40
▸ HTR1A P08908 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9933193 1.00 KCNA5 (0.49) KCNA5PLD1KCNE1SLC6A4CHRM2
SCHEMBL9933454 1.00 KCNA5 (0.49) KCNA5PLD1KCNE1SLC6A4CHRM2
Hydrochloric Acid SCHEMBL25270424 0.98 KCNA5 (0.47) KCNA5PLD1KCNE1SLC6A4CHRM2
Hydrochloric Acid SCHEMBL29090699 0.98 KCNA5 (0.47) KCNA5PLD1KCNE1SLC6A4CHRM2
SCHEMBL9933491 0.85 KCNA5 (0.56) KCNA5PLD1KCNE1SLC6A4CHRM2
SCHEMBL9933366 0.85 KCNA5 (0.56) KCNA5PLD1KCNE1SLC6A4CHRM2
SCHEMBL9668033 0.84 KCNA5 (0.68) KCNA5KCNE1SLC6A4CHRM2CHRM1
SCHEMBL30364157 0.84 KCNA5 (0.62) KCNA5KCNE1SLC6A4CHRM2CHRM1
SCHEMBL8304948 0.83 MEN1 (0.55) KCNA5PLD1KCNE1SLC6A4MEN1
SCHEMBL9318039 0.83 KCNA5 (0.71) KCNA5KCNE1SLC6A4CHRM2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104046246-B The chemical-mechanical planarization of tungsten-containing substrate 气体产品与化学公司 2016-06-15 — — CN claimed
US-20140273458-A1 Chemical Mechanical Planarization for Tungsten-Containing Substrates AIR PRODUCTS AND CHEMICALS, INC. (US) 2014-09-18 — — US claimed
EP-2779217-A2 Chemical mechanical planarization for tungsten-containing substrates AIR PRODUCTS AND CHEMICALS, INC. (US) 2014-09-17 — — EP claimed
CN-104046246-A Chemical Mechanical Planarization for Tungsten-Containing Substrates AIR PROD & CHEM 2014-09-17 — — CN claimed
CN-105008360-B The Pyrazolopyrimidine derivative of therapeutic activity UCB生物制药私人有限公司 2017-09-19 — — CN disclosed
CN-106559992-A As the bicyclic heteroaromatic derivative for condensing of kinase inhibitor UCB生物制药私人有限公司 2017-04-05 — — CN disclosed
CN-106507674-A Fused bicyclic heteroaromatic derivatives as kinase inhibitors UCB生物制药私人有限公司 2017-03-15 — — CN disclosed
CN-106459046-A Pyrazolo-pyridine derivatives as kinase inhibitors UCB生物制药私人有限公司 2017-02-22 — — CN disclosed
CN-104046246-B The chemical-mechanical planarization of tungsten-containing substrate 气体产品与化学公司 2016-06-15 — — CN disclosed
US-20140273458-A1 Chemical Mechanical Planarization for Tungsten-Containing Substrates AIR PRODUCTS AND CHEMICALS, INC. (US) 2014-09-18 — — US disclosed
EP-2779217-A2 Chemical mechanical planarization for tungsten-containing substrates AIR PRODUCTS AND CHEMICALS, INC. (US) 2014-09-17 — — EP disclosed
CN-104046246-A Chemical Mechanical Planarization for Tungsten-Containing Substrates AIR PROD & CHEM 2014-09-17 — — CN disclosed
US-20070032489-A1 SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) AVENTIS PHARMACEUTICALS INC. (US) 2007-02-08 — — US disclosed
US-20060160820-A1 Substituted piperazine carbamates NOVO NORDISK A/S (DK) 2006-07-20 — — US disclosed
EP-1636187-A1 SUBSTITUTED PIPERAZINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 — — EP disclosed
WO-2004111004-A1 SUBSTITUTED PIPERAZINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 — — WO disclosed
US-5215989-A Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents MERCK & CO., INC. (US) 1993-06-01 — — US disclosed
EP-0528172-A1 (2-Alkyl-3-pyridyl)methylpiperazine derivatives as PAF antagonists J. URIACH & CIA. S.A. (ES) 1993-02-24 — — EP disclosed
US-5032598-A Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents MERCK & CO., INC. (US) 1991-07-16 — — US disclosed
EP-0431945-A2 Antiarrhythmic agents MERCK & CO. INC. (US) 1991-06-12 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070032489-A1 SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) PARP1, PARP2, PARP3 KCNA5 1964/4885PLD1 1020/4885KCNE1 2668/4885
US-20060160820-A1 Substituted piperazine carbamates LIPE, PNLIP, LPL KCNA5 2765/4885PLD1 70/4885KCNE1 2839/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.