Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dimethylformamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylformamide SCHEMBL849515 | 0.97 | — | — | |
| Dimethylformamide SCHEMBL28317966 | 0.93 | TSHR (0.60) | TSHRALDH1A1USP2ALOX15MAPK1 | |
| Dimethylformamide SCHEMBL11302637 | 0.93 | — | — | |
| Dimethylformamide SCHEMBL3457497 | 0.93 | — | — | |
| Dimethylformamide SCHEMBL10405953 | 0.88 | TSHR (0.53) | TSHRALDH1A1USP2ALOX15MAPK1 | |
| Dimethylformamide SCHEMBL850064 | 0.86 | — | — | |
| Dimethylformamide SCHEMBL11264821 | 0.85 | TSHR (0.50) | TSHRALDH1A1USP2ALOX15TDP1 | |
| Dimethylformamide SCHEMBL8801229 | 0.84 | — | — | |
| Dimethylformamide SCHEMBL23282482 | 0.83 | TSHR (0.47) | TSHRALDH1A1USP2ALOX15 | |
| Ether SCHEMBL8913501 | 0.83 | TSHR (0.47) | TSHRALDH1A1USP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10766915-B2 | Metal-based coordination complexes as photodynamic compounds and their use | MCFARLAND SHERRI ANN (CA) | 2020-09-08 | — | — | US | disclosed |
| US-20160039854-A1 | METAL-BASED COORDINATION COMPLEXES AS PHOTODYNAMIC COMPOUNDS AND THEIR USE | MCFARLAND SHERRI ANN (CA) | 2016-02-11 | — | — | US | disclosed |
| US-8173642-B2 | Aminodihydrothiazine derivatives | SHIONOGI & CO., LTD. (JP) | 2012-05-08 | — | — | US | disclosed |
| US-20090082560-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2009-03-26 | — | — | US | disclosed |
| US-20060166982-A1 | Isotopically labelly indlinone derivatives and process for their preparation | PFIZER ITALIA S.R.L. (IT) | 2006-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039854-A1 | METAL-BASED COORDINATION COMPLEXES AS PHOTODYNAMIC COMPOUNDS AND THEIR USE | PIN1, PPIF, PPOX | TSHR 4598/4885ALDH1A1 2483/4885USP2 4124/4885 |
| US-10766915-B2 | Metal-based coordination complexes as photodynamic compounds and their use | PIN1, PPIF, PPOX | TSHR 4598/4885ALDH1A1 2483/4885USP2 4124/4885 |
| US-20060166982-A1 | Isotopically labelly indlinone derivatives and process for their preparation | CYP3A5, SLC10A2, TMEM14C | TSHR 2996/4885ALDH1A1 440/4885USP2 4195/4885 |
| US-20090082560-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | BACE1, BACE2, APP | TSHR 1912/4885ALDH1A1 1897/4885USP2 2418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.