Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.78 |
| ▸ | TSHR | P16473 | 2/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.78 |
| ▸ | TP53 | P04637 | 1/20 | 0.78 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.78 |
| ▸ | THRB | P10828 | 1/20 | 0.78 |
| ▸ | CASP1 | P29466 | 1/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.78 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL49805 | 0.89 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2CYP3A4ALOX15TSHR | |
| SCHEMBL9572276 | 0.82 | ALDH1A1 (0.86) | ALDH1A1SMN1; SMN2CYP3A4ALOX15TSHR | |
| SCHEMBL11482583 | 0.82 | ALDH1A1 (0.86) | ALDH1A1SMN1; SMN2CYP3A4ALOX15TSHR | |
| SCHEMBL1844486 | 0.82 | ALDH1A1 (0.86) | ALDH1A1SMN1; SMN2CYP3A4ALOX15TSHR | |
| SCHEMBL9874686 | 0.82 | ALDH1A1 (0.86) | ALDH1A1SMN1; SMN2CYP3A4ALOX15TSHR | |
| SCHEMBL15325739 | 0.81 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2CYP3A4ALOX15TSHR | |
| SCHEMBL11466441 | 0.80 | ALDH1A1 (0.82) | ALDH1A1SMN1; SMN2CYP3A4ALOX15TSHR | |
| SCHEMBL8559868 | 0.80 | ALDH1A1 (0.82) | ALDH1A1SMN1; SMN2CYP3A4ALOX15TSHR | |
| Methane SCHEMBL21294035 | 0.80 | ALDH1A1 (0.82) | ALDH1A1SMN1; SMN2CYP3A4ALOX15TSHR | |
| SCHEMBL3720674 | 0.78 | ALOX15 (0.78) | ALDH1A1SMN1; SMN2CYP3A4ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173849-B2 | Therapeutic compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| US-20100249246-A1 | Therapeutic Compounds | PHARMACOFORE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249246-A1 | Therapeutic Compounds | OPRM1, OGFR, UGT1A1 | ALDH1A1 112/4885SMN1; SMN2 131/4885CYP3A4 118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.