Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.46 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18407332 | 0.84 | ALDH1A1 (0.56) | ALDH1A1MAPK1SMN1; SMN2EGFRNPC1 | |
| SCHEMBL11134573 | 0.84 | ALDH1A1 (0.60) | ALDH1A1MAPK1SMN1; SMN2EGFRNPC1 | |
| SCHEMBL24112995 | 0.84 | HDAC4 (0.43) | ALDH1A1MAPK1SMN1; SMN2RAF1KDR | |
| SCHEMBL10993401 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPK1SMN1; SMN2EGFRNPC1 | |
| SCHEMBL11721019 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPK1SMN1; SMN2EGFRNPC1 | |
| SCHEMBL17663699 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPK1SMN1; SMN2EGFRRAF1 | |
| SCHEMBL14213302 | 0.79 | ALDH1A1 (0.50) | ALDH1A1MAPK1SMN1; SMN2EGFRNPC1 | |
| SCHEMBL1809204 | 0.79 | ALDH1A1 (0.50) | ALDH1A1MAPK1SMN1; SMN2EGFRRAF1 | |
| SCHEMBL5941035 | 0.78 | ALDH1A1 (0.51) | ALDH1A1MAPK1SMN1; SMN2EGFRRAF1 | |
| SCHEMBL17660276 | 0.77 | RAB9A (0.59) | ALDH1A1MAPK1SMN1; SMN2EGFRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230382909-A1 | BICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2023-11-30 | — | — | US | disclosed |
| US-20230382909-A1 | BICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2023-11-30 | — | — | US | disclosed |
| US-20230374008-A1 | BICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2023-11-23 | — | — | US | disclosed |
| US-20230374008-A1 | BICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2023-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230382909-A1 | BICYCLIC COMPOUNDS | SLC10A1, PKD1, CYP11B2 | ALDH1A1 543/4885MAPK1 2112/4885SMN1; SMN2 611/4885 |
| US-20230374008-A1 | BICYCLIC COMPOUNDS | SLC10A1, PKD1, CYP11B2 | ALDH1A1 543/4885MAPK1 2112/4885SMN1; SMN2 611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.