Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 8/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 7/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 5/20 | 0.35 |
| ▸ | HTR6 | P50406 | 6/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.34 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309512 | 0.94 | FLT3 (0.36) | ACVR1NOD2RIPK2HTR6BRD4 | |
| SCHEMBL26807471 | 0.91 | ACVR1 (0.40) | ACVR1NOD2RIPK2HTR6TGFBR1 | |
| SCHEMBL24310583 | 0.88 | RIPK2 (0.38) | ALOX12ACVR1NOD2RIPK2HTR6 | |
| SCHEMBL26807728 | 0.86 | FLT3 (0.37) | ACVR1NOD2RIPK2HTR6CDK4 | |
| SCHEMBL26807463 | 0.85 | ACVR1 (0.40) | ACVR1NOD2RIPK2HTR6TGFBR1 | |
| SCHEMBL26807316 | 0.85 | RIPK2 (0.39) | ACVR1NOD2RIPK2HTR6 | |
| SCHEMBL29566726 | 0.85 | RIPK2 (0.39) | ACVR1NOD2RIPK2HTR6 | |
| SCHEMBL26811472 | 0.85 | NOD2 (0.36) | ALOX12ACVR1NOD2RIPK2HTR6 | |
| SCHEMBL26809994 | 0.85 | GUSB (0.36) | ALOX12ACVR1NOD2RIPK2HTR6 | |
| SCHEMBL26807778 | 0.85 | HTR3E (0.46) | ACVR1NOD2RIPK2HTR6TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1G, SCNN1B | ALOX12 3292/4885ACVR1 1319/4885NOD2 724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.