Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.37 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | WRN | Q14191 | 1/20 | 0.33 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370 | 0.81 | HTR1A (0.40) | ALDH1A1KMT2AHTR2AHRH1SLC6A2 | |
| SCHEMBL21722780 | 0.78 | GABBR2 (0.41) | GABBR2GABBR1ALDH1A1KMT2ACYP3A4 | |
| SCHEMBL21722781 | 0.78 | GABBR2 (0.41) | GABBR2GABBR1ALDH1A1KMT2ACYP3A4 | |
| SCHEMBL23521673 | 0.78 | GABBR2 (0.41) | GABBR2GABBR1ALDH1A1KMT2ACYP3A4 | |
| SCHEMBL14353749 | 0.76 | CACNA2D1 (0.43) | MAPK1GABBR2GABBR1ALDH1A1KMT2A | |
| SCHEMBL22585593 | 0.76 | GABBR2 (0.42) | MAPK1GABBR2GABBR1ALDH1A1KMT2A | |
| SCHEMBL23258012 | 0.76 | GABBR2 (0.42) | MAPK1GABBR2GABBR1ALDH1A1KMT2A | |
| SCHEMBL5247316 | 0.74 | GABBR2 (0.43) | GABBR2GABBR1CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL5246292 | 0.74 | GABBR2 (0.43) | GABBR2GABBR1CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL5250926 | 0.74 | GABBR2 (0.43) | GABBR2GABBR1CYP3A4CYP2D6SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |