Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Propofol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 5/20 | 0.63 |
| ▸ | GABRB1 known ✓ | P18505 | 4/20 | 0.63 |
| ▸ | GABRB2 known ✓ | P47870 | 3/20 | 0.63 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.63 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.63 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.63 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.63 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.63 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.63 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.78 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.78 |
| ▸ | HTR2B | P41595 | 2/20 | 0.78 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.78 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.78 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.78 |
| ▸ | CA1 | P00915 | 2/20 | 0.63 |
| ▸ | CA2 | P00918 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thymol SCHEMBL22165 | 0.88 | LMNA (1.00) | LMNASLC6A2HTR2BTRPA1CHRM1 | |
| Thymol SCHEMBL29579824 | 0.88 | LMNA (1.00) | LMNASLC6A2HTR2BTRPA1CHRM1 | |
| Thymol SCHEMBL1867982 | 0.88 | LMNA (1.00) | LMNASLC6A2HTR2BTRPA1CHRM1 | |
| Thymol SCHEMBL30332213 | 0.88 | LMNA (1.00) | LMNASLC6A2HTR2BTRPA1CHRM1 | |
| Thymol SCHEMBL23932298 | 0.86 | LMNA (0.95) | LMNASLC6A2HTR2BTRPA1CHRM1 | |
| Thymol SCHEMBL11054439 | 0.86 | LMNA (0.95) | LMNASLC6A2HTR2BTRPA1CHRM1 | |
| Thymol SCHEMBL5905814 | 0.86 | LMNA (0.95) | LMNASLC6A2HTR2BTRPA1CHRM1 | |
| Thymol SCHEMBL7074408 | 0.86 | LMNA (0.95) | LMNASLC6A2HTR2BTRPA1CHRM1 | |
| Thymol SCHEMBL8506977 | 0.86 | LMNA (0.95) | LMNASLC6A2HTR2BTRPA1CHRM1 | |
| Thymol SCHEMBL1668335 | 0.86 | LMNA (0.95) | LMNASLC6A2HTR2BTRPA1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190167632-A1 | METHODS OF TREATING AND PREVENTING/REDUCING THE LIKELIHOOD OF MESIAL TEMPORAL LOBE EPILEPSY (TLE) | MUELLER WOLFGANG S (US) | 2019-06-06 | — | — | US | disclosed |
| US-10238622-B2 | Methods of treating and preventing/reducing the likelihood of Mesial temporal lobe epilepsy (TLE) | THE REGENTS OF THE UNIVERSITY OF NEW MEXICO | 2019-03-26 | — | — | US | disclosed |
| US-20120115919-A1 | METHODS OF TREATING AND PREVENTING/REDUCING THE LIKELIHOOD OF MESIAL TEMPORAL LOBE EPILEPSY (TLE) | THE REGENTS OF THE UNIVERSITY OF NEW MEXICO | 2012-05-10 | — | — | US | disclosed |