Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | USP19 | O94966 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23997226 | 0.86 | OPRM1 (0.37) | CYP11B1CYP11B2CHRM2CHRM3OPRM1 | |
| SCHEMBL18820451 | 0.85 | CHRM2 (0.49) | CYP11B1CYP11B2CHRM2CHRM3OPRM1 | |
| SCHEMBL17485296 | 0.84 | CYP11B1 (0.49) | TSHRCYP11B1CYP11B2CHRM2CHRM3 | |
| SCHEMBL18806140 | 0.81 | CHRM2 (0.34) | CYP11B1CYP11B2CHRM2CHRM3OPRM1 | |
| SCHEMBL17101510 | 0.80 | USP19 (0.38) | OPRM1OPRL1USP19 | |
| SCHEMBL18820444 | 0.79 | TSHR (0.44) | TSHRCYP11B1CYP11B2CHRM2CHRM3 | |
| SCHEMBL10111396 | 0.78 | TSHR (0.39) | TSHRCHRM2CHRM3OPRM1OPRL1 | |
| SCHEMBL26790423 | 0.78 | CYP11B1 (0.38) | TSHRCYP11B1CYP11B2CHRM2CHRM3 | |
| Hydrochloric Acid SCHEMBL18690044 | 0.76 | TSHR (0.41) | TSHRCHRM2CHRM3OPRM1OPRL1 | |
| SCHEMBL16190005 | 0.76 | HTR1A (0.38) | CYP11B1CYP11B2CHRM2CHRM3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220137-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |