Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | PRKX | P51817 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29232675 | 0.73 | BTK (0.57) | BTKTNK2LRRK2PLK4CHEK1 | |
| SCHEMBL12480000 | 0.72 | MAPT (0.41) | CHEK1FGFR1PTK2MAPTHTT | |
| SCHEMBL20674108 | 0.72 | ADORA2A (0.38) | BTKKDRLIMK1POLBHTT | |
| SCHEMBL29494919 | 0.71 | BTK (0.54) | BTKTNK2LRRK2PLK4CHEK1 | |
| SCHEMBL29696530 | 0.71 | CD38 (0.53) | BTKTNK2LRRK2PLK4CHEK1 | |
| SCHEMBL22932817 | 0.70 | CD38 (0.63) | — | |
| SCHEMBL12479029 | 0.69 | NOS1 (0.41) | CHEK1FGFR1PTK2MAPTHTT | |
| SCHEMBL29949484 | 0.69 | ALDH1A1 (0.46) | BTKLCKPOLBHTTALDH1A1 | |
| SCHEMBL24949665 | 0.68 | ALDH1A1 (0.42) | BTKTNK2LRRK2PLK4CHEK1 | |
| SCHEMBL1421939 | 0.68 | BTK (0.58) | BTKTNK2LRRK2PLK4CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023217906-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-16 | — | — | WO | disclosed |