Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24298714 | 0.88 | HDAC3 (0.42) | ALDH1A1L3MBTL1TSHRCASP3SENP8 | |
| SCHEMBL24324698 | 0.88 | SMN1; SMN2 (0.49) | LOXNAMPTALDH1A1L3MBTL1TSHR | |
| SCHEMBL26863010 | 0.87 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1TSHRCASP3SENP8 | |
| SCHEMBL26869586 | 0.86 | L3MBTL1 (0.35) | ALDH1A1L3MBTL1TSHRMEN1KMT2A | |
| SCHEMBL26837763 | 0.86 | CASP3 (0.42) | LOXALDH1A1CASP3SENP8SENP7 | |
| SCHEMBL26841506 | 0.85 | HSD11B1 (0.39) | ALDH1A1L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL26876181 | 0.84 | ALDH1A1 (0.33) | ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL26831776 | 0.84 | EGFR (0.38) | ALDH1A1L3MBTL1MEN1KMT2AHTT | |
| SCHEMBL26833740 | 0.83 | KMT2A (0.47) | ALDH1A1TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL26841429 | 0.83 | F2 (0.35) | ALDH1A1L3MBTL1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230382925-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2023-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230382925-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1G, SCNN1B | LOX 2676/4885NAMPT 1965/4885ALDH1A1 4032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.