⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4148747 | 1.00 | — | — | |
| SCHEMBL268870 | 1.00 | — | — | |
| Piperidine SCHEMBL9748748 | 0.82 | ALDH1A1 (0.33) | — | |
| SCHEMBL3355792 | 0.80 | — | — | |
| SCHEMBL15948049 | 0.80 | — | — | |
| SCHEMBL18047813 | 0.80 | — | — | |
| SCHEMBL3133846 | 0.79 | HDAC3 (0.43) | — | |
| SCHEMBL1556595 | 0.79 | FNTA (0.39) | — | |
| SCHEMBL12490349 | 0.79 | HDAC3 (0.43) | — | |
| SCHEMBL42601 | 0.78 | FFAR3 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 158 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130131126-A1 | DERIVATIVES OF 1,4-DIHYDROPYRIDINE POSSESSING ANTIVIRAL EFFICACY | JSC GRINDEKS (LV) | 2013-05-23 | — | — | US | claimed |
| EP-0534520-B1 | Process for the preparation of 4-substituted-1,4-dihydropyridines | MERCK & CO INC (US) | 1997-03-19 | — | — | EP | claimed |
| US-4042646-A | BETA-AMINO-ALPHA, BETA-UNSATURATED KETONE, POLYESTERS | NIHON YUSHI CO., LTD. (JA) | 1977-08-16 | — | — | US | claimed |
| US-20250214963-A1 | SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER INC. | 2025-07-03 | — | — | US | disclosed |
| US-20230348501-A1 | HETEROARYL INHIBITORS OF PDE4 | Tetra Discovery Partners, LLC | 2023-11-02 | — | — | US | disclosed |
| US-11767334-B2 | Heteroaryl inhibitors of PDE4 | Tetra Discovery Partners, LLC (US) | 2023-09-26 | — | — | US | disclosed |
| WO-2023169566-A1 | CATALYST FOR PHOTOCATALYTIC POLYMERIZATION REACTION, AND APPLICATION THEREOF | 北京服装学院 | 2023-09-14 | — | — | WO | disclosed |
| US-20230024240-A1 | HETEROARYL INHIBITORS OF PDE4 | Tetra Discovery Partners, LLC | 2023-01-26 | — | — | US | disclosed |
| EP-3842420-B1 | HETEROARYL INHIBITORS OF PDE4 | TETRA DISCOVERY PARTNERS LLC (US) | 2022-12-07 | — | — | EP | disclosed |
| US-20220251066-A1 | SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER INC. | 2022-08-11 | — | — | US | disclosed |
| CN-113713438-B | Efficient continuous deacidification device for chlorinated plasticizer and application method of efficient continuous deacidification device | 浙江镇洋发展股份有限公司 | 2022-07-26 | — | — | CN | disclosed |
| US-4845113-A | USEFUL IN RADICAL SCAVENGING THERAPY | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1989-07-04 | — | — | US | disclosed |
| US-4839348-A | HYPOTENSIVE AGENTS; ANTICOAGULANTS, ANTIISCHEMIC AGENTS | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1989-06-13 | — | — | US | disclosed |
| US-4801599-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS | GLAXO S.P.A. (IT) | 1989-01-31 | — | — | US | disclosed |
| EP-0245918-A1 | 1,4-Dihydropyridine derivatives | GLAXO S.p.A. (IT) | 1987-11-19 | — | — | EP | disclosed |
| EP-0212340-A1 | 2-(heteroalkyl)-1,4-dihydropyridines, process for their preparations and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1987-03-04 | — | — | EP | disclosed |
| EP-0210571-A1 | Phosphonopyridines and their 1,4-dihydroderivatives | BOEHRINGER BIOCHEMIA ROBIN S.p.A. (IT) | 1987-02-04 | — | — | EP | disclosed |
| US-4576949-A | Use of 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines as leukotriene and lipoxygenase inhibitors and the novel 3-substituted compounds therein | THE UPJOHN COMPANY (US) | 1986-03-18 | — | — | US | disclosed |
| EP-0161867-A2 | 5,6,7,8-Tetrahydroquinolines and 5,6-dihydropyrindines and their therapeutic use | THE UPJOHN COMPANY (US) | 1985-11-21 | — | — | EP | disclosed |
| US-4546186-A | 1,4,5,6,7,8-Hexahydro-2-methyl-5-oxo-4-(2-thiazolyl)-3-quinoline carboxylic acid 2-methyl(phenylmethyl)amino ethyl ester and pharmaceutically acceptable salts | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-10-08 | — | — | US | disclosed |