Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
| ▸ | F12 | P00748 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | GPR39 | O43194 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26885170 | 0.84 | GPR39 (0.34) | KDM4EGAAADORA2AADORA3CYP1A2 | |
| SCHEMBL20665643 | 0.77 | LMNA (0.41) | KDM4EGAAADORA2ALMNAPDE10A | |
| SCHEMBL20665129 | 0.72 | KDM4E (0.51) | KDM4EGAAADORA2ALMNAPDE10A | |
| SCHEMBL20665657 | 0.71 | HPGDS (0.35) | KDM4EGAAPDE10AALDH1A1HPGD | |
| SCHEMBL20665170 | 0.70 | L3MBTL1 (0.41) | KDM4EADORA2ALMNAALDH1A1CYP3A4 | |
| SCHEMBL26158139 | 0.66 | KDM4E (0.46) | KDM4EGAAADORA2APDE10AALDH1A1 | |
| SCHEMBL20665232 | 0.65 | KMT2A (0.40) | KDM4EGAALMNAHDAC3HDAC1 | |
| SCHEMBL20665735 | 0.64 | KDM4E (0.44) | KDM4EGAAADORA2APDE10AHDAC3 | |
| SCHEMBL24128049 | 0.64 | KDM4E (0.46) | KDM4EGAAPDE10AALDH1A1KMT2A | |
| SCHEMBL29720684 | 0.64 | KDM4E (0.46) | KDM4EGAAPDE10AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3642209-B1 | COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY Therapeutics LLC (US) | 2023-11-29 | — | — | EP | disclosed |