SCHEMBL2689488

SCHEMBL2689488

O=c1[nH]c2ccccc2c2cnccc12

nearest known ligand 0.87

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 11/20 0.87
KDM4E B2RXH2 4/20 0.66
ALDH1A1 P00352 3/20 0.66
MEN1 O00255 2/20 0.66
LMNA P02545 2/20 0.66
CYP1A2 P05177 2/20 0.66
BLM P54132 2/20 0.66
PMP22 Q01453 2/20 0.66
KMT2A Q03164 2/20 0.66
HSD17B10 Q99714 2/20 0.66
TNKS O95271 1/20 0.66
GPR3 P46089 1/20 0.66
PARP15 Q460N3 1/20 0.66
TNKS2 Q9H2K2 1/20 0.66
HPGD P15428 2/20 0.65
SMN1; SMN2 Q16637 2/20 0.65
AURKA O14965 2/20 0.65
ACHE P22303 1/20 0.65
GABRP O00591 1/20 0.65
GABRD O14764 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1900370 0.93 PARP1 (1.00) PARP1KDM4EALDH1A1MEN1LMNA
SCHEMBL9042961 0.90 PARP1 (0.76) PARP1KDM4EALDH1A1MEN1LMNA
SCHEMBL1478179 0.87 PARP1 (1.00) PARP1KDM4EALDH1A1MEN1LMNA
SCHEMBL12750475 0.87 PARP1 (1.00) PARP1KDM4EALDH1A1MEN1LMNA
SCHEMBL30704720 0.87 PARP1 (1.00) PARP1KDM4EALDH1A1MEN1LMNA
SCHEMBL29484414 0.87 PARP1 (0.79) PARP1KDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL10134605 0.87 PARP1 (0.79) PARP1KDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL10134606 0.87 PARP1 (0.79) PARP1KDM4EALDH1A1MEN1LMNA
SCHEMBL9040656 0.86 PARP1 (0.81) PARP1KDM4EALDH1A1MEN1LMNA
SCHEMBL9043755 0.84 PARP1 (0.81) PARP1KDM4EALDH1A1MEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3823958-B1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2023-08-23 EP disclosed
EP-3823958-B1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2023-08-23 EP disclosed
US-20220069231-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2022-03-03 US disclosed
EP-3823958-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES Merck Patent GmbH (DE) 2021-05-26 EP disclosed
WO-2020016264-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2020-01-23 WO disclosed
WO-2020016264-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2020-01-23 WO disclosed
US-9337430-B2 Organic electroluminescent device MERCK PATENT GMBH (DE) 2016-05-10 US disclosed
US-9337430-B2 Organic electroluminescent device MERCK PATENT GMBH (DE) 2016-05-10 US disclosed
US-9337430-B2 Organic electroluminescent device MERCK PATENT GMBH (DE) 2016-05-10 US disclosed
EP-2773721-B1 ORGANIC ELECTROLUMINESCENT DEVICE MERCK PATENT GMBH (DE) 2015-11-25 EP disclosed
US-20120208792-A1 PROTEIN KINASE MODULATORS CYLENE PHARMACEUTICALS, INC. (US) 2012-08-16 US disclosed
US-8168651-B2 Protein kinase modulators CYLENE PHARMACEUTICALS, INC. (US) 2012-05-01 US disclosed
US-8168651-B2 Protein kinase modulators CYLENE PHARMACEUTICALS, INC. (US) 2012-05-01 US disclosed
US-8168651-B2 Protein kinase modulators CYLENE PHARMACEUTICALS, INC. (US) 2012-05-01 US disclosed
EP-2259678-A1 PROTEIN KINASE MODULATORS Cylene Pharmaceuticals, Inc. (US) 2010-12-15 EP disclosed
US-20090239859-A1 PROTEIN KINASE MODULATORS SENHWA BIOSCIENCES, INC. (TW) 2009-09-24 US disclosed
US-20090239859-A1 PROTEIN KINASE MODULATORS SENHWA BIOSCIENCES, INC. (TW) 2009-09-24 US disclosed
US-20090239859-A1 PROTEIN KINASE MODULATORS SENHWA BIOSCIENCES, INC. (TW) 2009-09-24 US disclosed
WO-2009108912-A1 PROTEIN KINASE MODULATORS CYLENE PHARMACEUTICALS, INC. (US) 2009-09-03 WO disclosed
WO-2009108912-A1 PROTEIN KINASE MODULATORS CYLENE PHARMACEUTICALS, INC. (US) 2009-09-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220069231-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES PIEZO1, L1CAM, EFNA1 PARP1 1804/4885KDM4E 3334/4885ALDH1A1 95/4885
US-20120208792-A1 PROTEIN KINASE MODULATORS PIM1, PIM2, PIM3 PARP1 690/4885KDM4E 736/4885ALDH1A1 3801/4885
US-20090239859-A1 PROTEIN KINASE MODULATORS PIM1, PIM2, PIM3 PARP1 690/4885KDM4E 736/4885ALDH1A1 3801/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.