Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31512482 | 0.82 | AVPR1A (0.39) | BRPF1HSD17B3KMT2AMAPTMEN1 | |
| SCHEMBL8727463 | 0.82 | AVPR1A (0.39) | BRPF1HSD17B3KMT2AMAPTMEN1 | |
| SCHEMBL5458675 | 0.67 | BRPF1 (0.40) | BRPF1HSD17B3KMT2AMEN1GAA | |
| SCHEMBL4265285 | 0.66 | BRPF1 (0.41) | BRPF1HSD17B3KMT2AMAPTMEN1 | |
| SCHEMBL30738818 | 0.66 | BRPF1 (0.50) | BRPF1HSD17B3KMT2AMAPTMEN1 | |
| SCHEMBL28876634 | 0.66 | BRPF1 (0.41) | BRPF1HSD17B3KMT2AMEN1GAA | |
| SCHEMBL8304937 | 0.66 | BRPF1 (0.41) | BRPF1HSD17B3KMT2AMEN1GAA | |
| SCHEMBL9521938 | 0.66 | BRPF1 (0.41) | BRPF1HSD17B3KMT2AMAPTMEN1 | |
| SCHEMBL21400260 | 0.66 | BRPF1 (0.41) | BRPF1HSD17B3KMT2AMAPTMEN1 | |
| SCHEMBL17114712 | 0.66 | BRPF1 (0.41) | BRPF1HSD17B3KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168668-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-05-01 | — | — | US | disclosed |
| US-20100286202-A1 | New Compounds | ASTRAZENECA AB (SE) | 2010-11-11 | — | — | US | disclosed |
| US-7618993-B2 | Compounds | ASTRAZENECA AB (SE) | 2009-11-17 | — | — | US | disclosed |
| US-20080171770-A1 | Compounds | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286202-A1 | New Compounds | REN, PCSK9, FURIN | BRPF1 4211/4885HSD17B3 963/4885KMT2A 4014/4885 |
| US-20080171770-A1 | Compounds | REN, PCSK9, SLC10A1 | BRPF1 4176/4885HSD17B3 570/4885KMT2A 4011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.