Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29450350 | 0.98 | BRPF1 (0.40) | BRPF1GAAMEN1KMT2ABRD4 | |
| Pyridine SCHEMBL28814125 | 0.89 | BRPF1 (0.35) | BRPF1GAAMEN1KMT2ABRD4 | |
| SCHEMBL3311949 | 0.78 | AVPR1A (0.40) | BRPF1GAAMEN1KMT2ABRD4 | |
| SCHEMBL19054509 | 0.74 | BRPF1 (0.36) | BRPF1GAAMEN1KMT2ABRD4 | |
| SCHEMBL27738677 | 0.74 | ALDH1A1 (0.41) | BRPF1GAAMEN1KMT2ABRD4 | |
| SCHEMBL4013751 | 0.73 | BRPF1 (0.50) | BRPF1GAAMEN1KMT2ABRD4 | |
| SCHEMBL8304937 | 0.73 | BRPF1 (0.41) | BRPF1GAAMEN1KMT2ABRD4 | |
| SCHEMBL21400260 | 0.73 | BRPF1 (0.41) | BRPF1GAAMEN1KMT2ABRD4 | |
| SCHEMBL17114712 | 0.73 | BRPF1 (0.41) | BRPF1GAAMEN1KMT2ABRD4 | |
| SCHEMBL9521938 | 0.73 | BRPF1 (0.41) | BRPF1GAAMEN1KMT2ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090022729-A1 | METHODS AND COMPOSITIONS FOR TREATING CARDIAC DYSFUNCTIONS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-01-22 | — | — | US | claimed |
| US-20210147478-A1 | INHIBITORS OF BLOOD COAGULATION FACTOR XIII | ZEDIRA GMBH (DE) | 2021-05-20 | — | — | US | disclosed |
| US-10064861-B2 | Macrocyclic pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2018-09-04 | — | — | US | disclosed |
| EP-2953952-B1 | MACROCYCLIC PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-06-07 | — | — | EP | disclosed |
| US-20170143713-A1 | MACROCYCLIC PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-05-25 | — | — | US | disclosed |
| US-9550794-B2 | Macrocyclic pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2017-01-24 | — | — | US | disclosed |
| US-20150376206-A1 | MACROCYCLIC PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-12-31 | — | — | US | disclosed |
| EP-2953952-A1 | MACROCYCLIC PYRIDAZINONE DERIVATIVES | Merck Patent GmbH (DE) | 2015-12-16 | — | — | EP | disclosed |
| CN-105008371-A | Macrocyclic pyridazinone derivatives | MERCK PATENT GMBH | 2015-10-28 | — | — | CN | disclosed |
| WO-2014121942-A1 | MACROCYCLIC PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-08-14 | — | — | WO | disclosed |
| US-20090022729-A1 | METHODS AND COMPOSITIONS FOR TREATING CARDIAC DYSFUNCTIONS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-01-22 | — | — | US | disclosed |
| US-4766110-A | INHIBITS ANGIOTENSIN CONVERTING ENZYME, HYPOTENSIVE AGENTS | RYAN JAMES W (US) | 1988-08-23 | — | — | US | disclosed |
| EP-0073143-B1 | NOVEL COMPLEX AMIDO AND IMIDO DERIVATIVES OF CARBOXYALKYL PEPTIDES AND THIOETHERS AND ETHERS OF PEPTIDES | Ryan, James Walter (US) | 1985-11-21 | — | — | EP | disclosed |
| EP-0073143-A2 | Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides | Ryan, James Walter (US) | 1983-03-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10064861-B2 | Macrocyclic pyridazinone derivatives | C5, PDXK, CYP1A2 | BRPF1 1480/4885GAA 2397/4885MEN1 320/4885 |
| US-20170143713-A1 | MACROCYCLIC PYRIDAZINONE DERIVATIVES | C5, PDXK, CYP1A2 | BRPF1 1480/4885GAA 2397/4885MEN1 320/4885 |
| US-20210147478-A1 | INHIBITORS OF BLOOD COAGULATION FACTOR XIII | TFPI, F11, F13B | BRPF1 1850/4885GAA 606/4885MEN1 1959/4885 |
| US-20090022729-A1 | METHODS AND COMPOSITIONS FOR TREATING CARDIAC DYSFUNCTIONS | TNNI3, MYLK2, FABP3 | BRPF1 1959/4885GAA 3197/4885MEN1 4466/4885 |
| US-20150376206-A1 | MACROCYCLIC PYRIDAZINONE DERIVATIVES | CYP1A1, VDR, NQO1 | BRPF1 1700/4885GAA 2663/4885MEN1 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.