Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 14/20 | 0.61 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PKLR | P30613 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 2/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14844510 | 0.84 | NPBWR1 (0.67) | NPBWR1MCHR1PKMPKLRALDH1A1 | |
| SCHEMBL21521858 | 0.83 | NPBWR1 (0.61) | NPBWR1MCHR1PKMPKLRALDH1A1 | |
| SCHEMBL31140676 | 0.82 | NPBWR1 (0.56) | NPBWR1MCHR1ALDH1A1PDE1APDE1B | |
| SCHEMBL26915070 | 0.80 | NPBWR1 (0.57) | NPBWR1MCHR1PKMPKLRALDH1A1 | |
| SCHEMBL21521851 | 0.80 | NPBWR1 (0.61) | NPBWR1MCHR1PKMPKLRALDH1A1 | |
| SCHEMBL29731534 | 0.80 | NPBWR1 (0.57) | NPBWR1MCHR1PKMPKLRALDH1A1 | |
| SCHEMBL27176044 | 0.80 | NPBWR1 (0.57) | NPBWR1MCHR1PKMPKLRALDH1A1 | |
| SCHEMBL14844531 | 0.78 | NPBWR1 (0.84) | NPBWR1MCHR1ALDH1A1HTT | |
| SCHEMBL25723425 | 0.77 | NPBWR1 (0.64) | NPBWR1MCHR1PKMPKLRALDH1A1 | |
| SCHEMBL2551062 | 0.77 | NPBWR1 (0.77) | NPBWR1MCHR1PKMALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240166664-A1 | TRIHETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | SHANGHAI APEIRON THERAPEUTICS COMPANY LIMITED (CN) | 2024-05-23 | — | — | US | disclosed |
| EP-4289845-A1 | TRIHETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | Shanghai Apeiron Therapeutics Company Limited (CN) | 2023-12-13 | — | — | EP | disclosed |
| CN-116724044-A | Tri-heterocyclic compound, preparation method and application thereof | 上海湃隆生物科技有限公司 | 2023-09-08 | — | — | CN | disclosed |
| WO-2022166749-A1 | TRIHETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海湃隆生物科技有限公司 | 2022-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240166664-A1 | TRIHETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, WEE1, WEE2 | NPBWR1 796/4885MCHR1 4541/4885PKM 3787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.