Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 15/20 | 0.77 |
| ▸ | HTT | P42858 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.67 |
| ▸ | MITF | O75030 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.61 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14844531 | 0.90 | NPBWR1 (0.84) | NPBWR1HTTALDH1A1SMN1; SMN2MCHR1 | |
| SCHEMBL24687649 | 0.87 | NPBWR1 (0.75) | NPBWR1HTTALDH1A1SMN1; SMN2MCHR1 | |
| SCHEMBL14844510 | 0.87 | NPBWR1 (0.67) | NPBWR1HTTALDH1A1SMN1; SMN2MCHR1 | |
| SCHEMBL19000707 | 0.85 | HTT (0.70) | NPBWR1HTTALDH1A1SMN1; SMN2MCHR1 | |
| SCHEMBL9736936 | 0.83 | HTT (0.64) | NPBWR1HTTALDH1A1SMN1; SMN2MCHR1 | |
| SCHEMBL27077877 | 0.83 | NPBWR1 (0.66) | NPBWR1HTTALDH1A1SMN1; SMN2MCHR1 | |
| SCHEMBL19000706 | 0.83 | HTT (0.77) | NPBWR1HTTALDH1A1SMN1; SMN2MCHR1 | |
| SCHEMBL29102671 | 0.82 | NPBWR1 (0.68) | NPBWR1HTTALDH1A1SMN1; SMN2MCHR1 | |
| SCHEMBL21521514 | 0.82 | NPBWR1 (0.71) | NPBWR1HTTALDH1A1SMN1; SMN2MCHR1 | |
| SCHEMBL24640867 | 0.82 | NPBWR1 (0.68) | NPBWR1HTTALDH1A1SMN1; SMN2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12441708-B2 | Cereblon ligands and bifunctional compounds comprising the same | ARVINAS OPERATIONS, INC. (US) | 2025-10-14 | — | — | US | disclosed |
| US-20250313547-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS INC (US) | 2025-10-09 | — | — | US | disclosed |
| US-20240417406-A1 | NITROGEN-CONTAINING TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2024-12-19 | — | — | US | disclosed |
| EP-4438040-A1 | NITROGEN-CONTAINING TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | Japan Tobacco Inc. (JP) | 2024-10-02 | — | — | EP | disclosed |
| US-20240217968-A1 | PHARMACEUTICAL COMPOUND | Duke Street Bio Limited (GB) | 2024-07-04 | — | — | US | disclosed |
| US-20240217968-A1 | PHARMACEUTICAL COMPOUND | Duke Street Bio Limited (GB) | 2024-07-04 | — | — | US | disclosed |
| CN-117897382-A | Nitrogen-containing tricyclic compounds and pharmaceutical uses thereof | 日本烟草产业株式会社 | 2024-04-16 | — | — | CN | disclosed |
| WO-2024061554-A1 | PHARMACEUTICAL COMPOUND | Duke Street Bio Limited (GB) | 2024-03-28 | — | — | WO | disclosed |
| WO-2024061554-A1 | PHARMACEUTICAL COMPOUND | Duke Street Bio Limited (GB) | 2024-03-28 | — | — | WO | disclosed |
| EP-4313300-A1 | PHARMACEUTICAL COMPOUND | Duke Street Bio Limited (GB) | 2024-02-07 | — | — | EP | disclosed |
| EP-2763968-B1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | SYNGENTA LTD (GB) | 2016-02-24 | — | — | EP | disclosed |
| EP-2342179-B1 | COMPOUNDS FOR INHIBITING SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) / VASCULAR ADHESION PROTEIN-1 (VAP-1) AND USES THEREOF FOR TREATMENT AND PREVENTION OF DISEASES | SEMMELWEIS EGYETEM (HU) | 2015-05-27 | — | — | EP | disclosed |
| US-20140256546-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | SYNGENTA LIMITED (GB) | 2014-09-11 | — | — | US | disclosed |
| EP-2763968-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | Syngenta Limited (GB) | 2014-08-13 | — | — | EP | disclosed |
| US-8536210-B2 | Compounds for inhibiting semicarbazide-sensitive amine oxidase (SSAO)/vascular adhesion protein-1 (VAP-1) and uses thereof for treatment and prevention of diseases | SEMMELWEIS EGYETEM (HU) | 2013-09-17 | — | — | US | disclosed |
| WO-2013050421-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | SYNGENTA LIMITED (GB) | 2013-04-11 | — | — | WO | disclosed |
| US-20110263567-A1 | COMPOUNDS FOR INHIBITING SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) / VASCULAR ADHESION PROTEIN-1 (VAP-1) AND USES THEREOF FOR TREATMENT AND PREVENTION OF DISEASES | SEMMELWEIS EGYETEM (HU) | 2011-10-27 | — | — | US | disclosed |
| US-5395934-A | Antiarrhythmia agents and cardiovascular disorders | EGIS GYOGYSZERGYAR (HU) | 1995-03-07 | — | — | US | disclosed |
| EP-0517877-A1 | NOVEL 3(2H)-PYRIDAZINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1992-12-16 | — | — | EP | disclosed |
| WO-1992012137-A1 | NOVEL 3(2H)-PYRIDAZINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1992-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240217968-A1 | PHARMACEUTICAL COMPOUND | F11, F12, ZYX | NPBWR1 830/4885HTT 3616/4885ALDH1A1 2181/4885 |
| US-20110263567-A1 | COMPOUNDS FOR INHIBITING SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) / VASCULAR ADHESION PROTEIN-1 (VAP-1) AND USES THEREOF FOR TREATMENT AND PREVENTION OF DISEASES | VCAM1, AOX1, AOC3 | NPBWR1 1079/4885HTT 2706/4885ALDH1A1 44/4885 |
| US-20250313547-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | CRBN, CBL, MDM2 | NPBWR1 3904/4885HTT 1235/4885ALDH1A1 3671/4885 |
| US-20240417406-A1 | NITROGEN-CONTAINING TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | PC, PCK2, AGK | NPBWR1 2166/4885HTT 991/4885ALDH1A1 1567/4885 |
| US-20140256546-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | PRDX6, PRDX1, CBR3 | NPBWR1 926/4885HTT 3989/4885ALDH1A1 861/4885 |
| US-12441708-B2 | Cereblon ligands and bifunctional compounds comprising the same | CRBN, CBL, MDM2 | NPBWR1 3904/4885HTT 1235/4885ALDH1A1 3671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.