Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 6/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.37 |
| ▸ | SOD3 | P08294 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31729661 | 0.88 | GNAO1 (0.45) | GNAO1GNAI3GNAI1TLR8TLR7 | |
| SCHEMBL13976317 | 0.88 | GNAO1 (0.45) | GNAO1GNAI3GNAI1TLR8TLR7 | |
| SCHEMBL25408317 | 0.88 | GNAO1 (0.45) | GNAO1GNAI3GNAI1TLR8TLR7 | |
| SCHEMBL20979276 | 0.85 | CARM1 (0.39) | GNAO1GNAI3GNAI1TLR8TLR7 | |
| SCHEMBL21348179 | 0.85 | USP2 (0.44) | GNAO1GNAI3GNAI1TLR8TLR7 | |
| SCHEMBL21730424 | 0.84 | HRH3 (0.41) | GNAO1GNAI3GNAI1USP2ALDH1A1 | |
| SCHEMBL20333633 | 0.84 | USP2 (0.43) | GNAO1GNAI3GNAI1TLR8TLR7 | |
| SCHEMBL9322304 | 0.81 | CARM1 (0.41) | GNAO1GNAI3GNAI1TLR8TLR7 | |
| SCHEMBL26941612 | 0.81 | CARM1 (0.41) | GNAO1GNAI3GNAI1USP2ALDH1A1 | |
| SCHEMBL21730510 | 0.80 | HRH3 (0.44) | GNAO1GNAI3GNAI1USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230399303-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | UNIV YALE (US) | 2023-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230399303-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | MIF, MMP12, METAP1 | GNAO1 3817/4885GNAI3 2132/4885GNAI1 2532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.