Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.39 |
| ▸ | HTR3B | O95264 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12516764 | 0.81 | HTR3E (0.50) | ALDH1A1MAPTPOLBRAD52HTR3E | |
| SCHEMBL28410275 | 0.78 | ALDH1A1 (0.56) | CASP1TSHRALDH1A1SIGMAR1CYP3A4 | |
| SCHEMBL24423487 | 0.78 | ALDH1A1 (0.56) | CASP1TSHRALDH1A1SIGMAR1CYP3A4 | |
| SCHEMBL10228517 | 0.74 | ALDH1A1 (0.52) | CASP1TSHRALDH1A1SIGMAR1CYP3A4 | |
| SCHEMBL26405492 | 0.74 | ALDH1A1 (0.52) | CASP1TSHRALDH1A1SIGMAR1CYP3A4 | |
| SCHEMBL12945123 | 0.73 | CYP3A4 (0.63) | CASP1TSHRALDH1A1SIGMAR1CYP3A4 | |
| SCHEMBL20707685 | 0.73 | CASP1 (0.41) | CASP1TSHRALDH1A1SIGMAR1CYP3A4 | |
| SCHEMBL23719168 | 0.72 | CASP1 (0.38) | CASP1TSHRALDH1A1SIGMAR1CYP3A4 | |
| SCHEMBL30084867 | 0.71 | SIGMAR1 (0.58) | TSHRSIGMAR1CYP3A4GRIN2DGRIN3B | |
| SCHEMBL1931049 | 0.71 | SIGMAR1 (0.58) | TSHRSIGMAR1CYP3A4GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074095-B1 | PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF | ITALIANA SINT SPA (IT) | 2014-07-02 | — | — | EP | claimed |
| CN-101528700-B | Process for preparing imatinib and intermediates thereof | ITALIANA SINT SPA | 2012-05-30 | — | — | CN | claimed |
| US-8168787-B2 | Process for the preparation of imatinib and intermediates thereof | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2012-05-01 | — | — | US | claimed |
| US-20100076189-A1 | PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2010-03-25 | — | — | US | claimed |
| CN-101528700-A | Process for preparing imatinib and intermediates thereof | ITALIANA SINT SPA (IT) | 2009-09-09 | — | — | CN | claimed |
| EP-2074095-A2 | PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF | F.I.S. Fabbrica Italiana Sintetici S.p.A. (IT) | 2009-07-01 | — | — | EP | claimed |
| WO-2008059551-A2 | PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2008-05-22 | — | — | WO | claimed |
| CN-107089969-B | Method for synthesizing imatinib intermediate | 黑龙江鑫创生物科技开发有限公司 | 2020-04-24 | — | — | CN | disclosed |
| CN-104910101-A | Synthesis process of imatinib intermediate 4-(4-methylpiperazin-1-ylmethyl) benzoic acid hydrochloride | WUHAN LIBAORUI MEDICINE SCIENCE & TECHNOLOGY CO LTD | 2015-09-16 | — | — | CN | disclosed |
| EP-2074095-B1 | PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF | ITALIANA SINT SPA (IT) | 2014-07-02 | — | — | EP | disclosed |
| US-8334381-B2 | Process for the preparation of intermediates useful in the synthesis of imatinib | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2012-12-18 | — | — | US | disclosed |
| CN-101528700-B | Process for preparing imatinib and intermediates thereof | ITALIANA SINT SPA | 2012-05-30 | — | — | CN | disclosed |
| US-8168787-B2 | Process for the preparation of imatinib and intermediates thereof | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2012-05-01 | — | — | US | disclosed |
| US-20100234598-A1 | PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF | FALCHI ALESSANDRO | 2010-09-16 | — | — | US | disclosed |
| US-20100076189-A1 | PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2010-03-25 | — | — | US | disclosed |
| CN-101528700-A | Process for preparing imatinib and intermediates thereof | ITALIANA SINT SPA (IT) | 2009-09-09 | — | — | CN | disclosed |
| EP-2074095-A2 | PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF | F.I.S. Fabbrica Italiana Sintetici S.p.A. (IT) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008059551-A2 | PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076189-A1 | PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF | ABL1, PDGFRA, ABL2 | CASP1 2969/4885TSHR 3719/4885ALDH1A1 571/4885 |
| US-20100234598-A1 | PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF | ABL1, PDGFRA, ABL2 | CASP1 2969/4885TSHR 3719/4885ALDH1A1 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.