Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 8/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26969755 | 0.88 | ACLY (0.39) | ACLYNPY5RNOTUMMEN1KMT2A | |
| SCHEMBL30733431 | 0.85 | KDM2B (0.43) | ACLYNPY5RNOTUMMEN1KMT2A | |
| SCHEMBL25281852 | 0.79 | MEN1 (0.54) | ACLYNPY5RNOTUMMEN1KMT2A | |
| SCHEMBL29386556 | 0.79 | MEN1 (0.54) | ACLYNPY5RNOTUMMEN1KMT2A | |
| SCHEMBL26969780 | 0.76 | ACLY (0.44) | ACLYNPY5RNOTUMMEN1KMT2A | |
| SCHEMBL25276068 | 0.75 | KMT2A (0.43) | ACLYNOTUMMEN1KMT2AATM | |
| SCHEMBL30733434 | 0.75 | LMNA (0.41) | ACLYNPY5RNOTUMMEN1KMT2A | |
| SCHEMBL30733405 | 0.74 | TSHR (0.50) | ACLYNOTUMMEN1KMT2A | |
| SCHEMBL30733408 | 0.74 | KMT2A (0.43) | ACLYNPY5RNOTUMKMT2A | |
| SCHEMBL30733401 | 0.73 | NOTUM (0.45) | ACLYNPY5RNOTUMCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | ACLY 3265/4885NPY5R 681/4885NOTUM 2050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.