Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 15/20 | 0.42 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.41 |
| ▸ | GNRHR | P30968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25236263 | 0.84 | HDAC1 (0.53) | TACR1NPY5RNPC1L1 | |
| SCHEMBL25274911 | 0.84 | NPY5R (0.43) | TACR1NPY5RGNRHR | |
| SCHEMBL26969775 | 0.84 | NPC1L1 (0.42) | KCNH2TACR1NPY5RNPC1L1GNRHR | |
| SCHEMBL26969704 | 0.83 | NPY5R (0.43) | TACR1NPY5RGNRHR | |
| SCHEMBL26969700 | 0.82 | HDAC1 (0.46) | TACR1NPY5RNPC1L1 | |
| SCHEMBL26969733 | 0.81 | NPY5R (0.60) | TACR1NPY5R | |
| SCHEMBL25231615 | 0.81 | NPY5R (0.41) | KCNH2TACR1NPY5RNPC1L1 | |
| SCHEMBL25237936 | 0.81 | ACLY (0.41) | TACR1NPY5RGNRHR | |
| SCHEMBL26969770 | 0.80 | NPY5R (0.40) | NPY5RGNRHR | |
| SCHEMBL25239332 | 0.80 | NPY5R (0.47) | NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | KCNH2 127/4885TACR1 398/4885NPY5R 681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.