Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | PKLR | P30613 | 2/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 10/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26969764 | 0.91 | ACLY (0.41) | ACLYCNR1MEN1ALDH1A1KMT2A | |
| SCHEMBL25276068 | 0.78 | KMT2A (0.43) | ACLYMEN1ALDH1A1KMT2ANOTUM | |
| SCHEMBL25280230 | 0.78 | ACLY (0.40) | ACLYMEN1ALDH1A1KMT2ANOTUM | |
| SCHEMBL30733423 | 0.76 | KCNN4 (0.47) | ACLYALDH1A1KMT2ANOTUMGAA | |
| SCHEMBL30733401 | 0.76 | NOTUM (0.45) | ACLYNOTUMNPY5R | |
| SCHEMBL26969734 | 0.76 | MMP2 (0.44) | ACLYMEN1ALDH1A1KMT2ANOTUM | |
| SCHEMBL29386556 | 0.75 | MEN1 (0.54) | ACLYMEN1ALDH1A1KMT2ANOTUM | |
| SCHEMBL25281852 | 0.75 | MEN1 (0.54) | ACLYMEN1ALDH1A1KMT2ANOTUM | |
| SCHEMBL30733405 | 0.75 | TSHR (0.50) | ACLYMEN1ALDH1A1KMT2ANOTUM | |
| SCHEMBL30733408 | 0.75 | KMT2A (0.43) | ACLYKMT2ANOTUMMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | ACLY 3265/4885CNR1 155/4885MEN1 782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.