Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23212816 | 0.82 | SRD5A1 (0.39) | — | |
| Hydrochloric Acid SCHEMBL23212926 | 0.81 | SRD5A1 (0.38) | — | |
| SCHEMBL22619811 | 0.76 | HTR6 (0.41) | — | |
| Hydrochloric Acid SCHEMBL22619864 | 0.74 | IDO1 (0.41) | — | |
| Hydrochloric Acid SCHEMBL22619807 | 0.74 | IDO1 (0.41) | — | |
| SCHEMBL23212917 | 0.74 | CTSD (0.45) | — | |
| SCHEMBL23212732 | 0.68 | CHRNA7 (0.45) | — | |
| Hydrochloric Acid SCHEMBL23212660 | 0.67 | IDO1 (0.44) | — | |
| SCHEMBL16800643 | 0.66 | GFRA3 (0.43) | CHRNB2CHRNA4 | |
| SCHEMBL18094367 | 0.66 | GFRA3 (0.43) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4210694-B1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-10-15 | — | — | EP | disclosed |
| US-20230416227-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416227-A1 | PLASMA KALLIKREIN INHIBITORS | KLKB1, SERPINE1, KLK5 | CHRNB2 4573/4885CHRNA4 4661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.