SCHEMBL2697397

SCHEMBL2697397

[c]1cnc(Cc2ccccc2)nc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CALM1 P0DP23 1/20 0.48
TAAR1 Q96RJ0 2/20 0.44
HRH3 Q9Y5N1 1/20 0.39
ALDH1A1 P00352 2/20 0.39
TRPA1 O75762 1/20 0.39
TSHR P16473 1/20 0.39
CYP3A4 P08684 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MAPT P10636 1/20 0.38
AOC3 Q16853 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
CHRM4 P08173 1/20 0.37
CHRM5 P08912 1/20 0.37
CHRM1 P11229 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL460058 0.78 CALM1 (0.55) CALM1TAAR1HRH3ALDH1A1TRPA1
Ammonia Solution, Strong SCHEMBL27509627 0.76 CALM1 (0.52) CALM1TAAR1HRH3ALDH1A1TRPA1
SCHEMBL8654460 0.76 CALM1 (0.52) CALM1TAAR1HRH3ALDH1A1TRPA1
SCHEMBL2163588 0.74 CALM1 (0.50) CALM1TAAR1HRH3ALDH1A1TRPA1
SCHEMBL1711863 0.72 CALM1 (0.42) CALM1TAAR1ALDH1A1CYP3A4KDM4E
SCHEMBL15323022 0.72 CALM1 (0.61) CALM1TAAR1HRH3ALDH1A1TRPA1
SCHEMBL2614741 0.72 CALM1 (0.61) CALM1TAAR1HRH3ALDH1A1TSHR
SCHEMBL16900004 0.71 TAAR1 (0.47) CALM1TAAR1HRH3ALDH1A1TSHR
SCHEMBL26146383 0.71 CALM1 (0.46) CALM1TAAR1HRH3ALDH1A1TRPA1
SCHEMBL13437610 0.71 AOC3 (0.48) CALM1TAAR1HRH3ALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8993776-B2 Heterocyclic alkanol derivatives BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-31 US disclosed
EP-2576525-B1 Heterocyclic alkanol derivatives as fungicides BAYER IP GMBH (DE) 2014-05-14 EP disclosed
US-8575356-B2 Heterocyclic alkanol derivatives BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-11-05 US disclosed
US-20130197236-A1 Novel Heterocyclic Alkanol Derivatives BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-08-01 US disclosed
US-20120108423-A1 Novel Heterocyclic Alkanol Derivatives BAYER CROPSCIENCE AG (DE) 2012-05-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120108423-A1 Novel Heterocyclic Alkanol Derivatives ERG28, CBR3, MYB CALM1 2924/4885TAAR1 1058/4885HRH3 1567/4885
US-20130197236-A1 Novel Heterocyclic Alkanol Derivatives ERG28, CBR3, MYB CALM1 2924/4885TAAR1 1058/4885HRH3 1567/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.