Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10772882 | 0.77 | SLC6A2 (0.40) | HTR2AHTR3EHTR3BCYP2D6HTR3A | |
| SCHEMBL8670994 | 0.73 | TDP1 (0.42) | HTR2AHTR3EHTR3BCYP1A2HTR1A | |
| SCHEMBL8670992 | 0.71 | HTR2C (0.43) | HTR2AHTR3EHTR3BCYP1A2HTR1A | |
| SCHEMBL6363783 | 0.71 | KDM4E (0.34) | HTR2ASIGMAR1TAAR1KDM4EALDH1A1 | |
| SCHEMBL4432187 | 0.71 | HTR2C (0.46) | HTR2ATAAR1HTR2CHTR2BKDM1A | |
| SCHEMBL28019268 | 0.68 | HTR2C (0.44) | HTR2ATAAR1KDM4EHTR2CHTR2B | |
| SCHEMBL10681131 | 0.67 | EGFR (0.41) | KDM4EALDH1A1MTNR1AEGFRERBB2 | |
| SCHEMBL4430758 | 0.67 | HTR2C (0.50) | HTR2ATAAR1HTR2CHTR2B | |
| SCHEMBL8811877 | 0.66 | MEN1 (0.38) | CYP2D6HTR6SIGMAR1TDP1SLC6A4 | |
| SCHEMBL8878356 | 0.64 | MTNR1A (0.53) | HTR6HTR2CMTNR1AKDM1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2896624-B1 | Heterotricyclic compounds as serotonergic and/or dopaminergic agents and uses thereof | ATIR HOLDING S A (LU) | 2016-07-13 | — | — | EP | disclosed |
| EP-2142541-B1 | HETEROTRICYCLIC COMPOUNDS AS SEROTONERGIC AND/OR DOPAMINERGIC AGENTS AND USES THEREOF | ATIR HOLDING S A (LU) | 2016-03-30 | — | — | EP | disclosed |
| EP-2896624-A1 | Heterotricyclic compounds as serotonergic and/or dopaminergic agents and uses thereof | Atir Holding S.A. (LU) | 2015-07-22 | — | — | EP | disclosed |
| US-8168639-B2 | Heterotricyclic compounds as serotonergic and/or dopaminergic agents and uses thereof | ATIR HOLDING S.A. (LU) | 2012-05-01 | — | — | US | disclosed |
| US-20100216807-A1 | HETEROCYCLIC COMPOUNDS AS SEROTONERGIC AND / OR DOPAMINERGIC AGENTS AND USES THEREOF | ATIR Holding S.A (LU) | 2010-08-26 | — | — | US | disclosed |
| EP-2142541-A2 | HETEROTRICYCLIC COMPOUNDS AS SEROTONERGIC AND/OR DOPAMINERGIC AGENTS AND USES THEREOF | Atir Holding S.A. (LU) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008117269-A2 | HETEROTRI CYCIII C COMPOUNDS AS SEROTONERGIC AND/OR DOPAMINERGIC AGENTS AND USES THEREOF | ATIR HOLDING S.A. (LU) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216807-A1 | HETEROCYCLIC COMPOUNDS AS SEROTONERGIC AND / OR DOPAMINERGIC AGENTS AND USES THEREOF | HTR1A, HTR1B, HTR1D | HTR2A 17/4885HTR3E 32/4885HTR3B 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.