Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.56 |
| ▸ | RXRB | P28702 | 6/20 | 0.56 |
| ▸ | RXRG | P48443 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2697721 | 1.00 | RXRA (0.56) | RXRARXRBRXRGMAPTALDH1A1 | |
| SCHEMBL2697768 | 0.89 | MAPT (0.50) | RXRARXRBMAPTALDH1A1KDM4E | |
| SCHEMBL2697770 | 0.89 | MAPT (0.50) | RXRARXRBMAPTALDH1A1KDM4E | |
| SCHEMBL2700540 | 0.89 | MAPT (0.50) | RXRARXRBMAPTALDH1A1KDM4E | |
| SCHEMBL25142179 | 0.84 | MAPT (0.54) | MAPTALDH1A1KDM4ELMNAHTT | |
| SCHEMBL2696125 | 0.82 | RXRA (0.56) | RXRARXRBRXRGALDH1A1TPMT | |
| SCHEMBL2696129 | 0.82 | RXRA (0.56) | RXRARXRBRXRGALDH1A1TPMT | |
| SCHEMBL2698824 | 0.80 | RXRA (0.45) | RXRARXRBRXRGALDH1A1HDAC1 | |
| SCHEMBL2698826 | 0.80 | RXRA (0.45) | RXRARXRBRXRGALDH1A1HDAC1 | |
| SCHEMBL2700543 | 0.80 | CYP1A2 (0.54) | RXRARXRBRXRGALDH1A1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580827-B2 | Anti-Francisella agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-11-12 | — | — | US | disclosed |
| EP-2246332-B1 | Pyrazole derivatives as anti-francisella agents | UNIV OHIO STATE RES FOUND (US) | 2013-09-18 | — | — | EP | disclosed |
| US-20120108823-A1 | ANTI-FRANCISELLA AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-05-03 | — | — | US | disclosed |
| EP-2246332-A1 | Pyrazole derivatives as anti-francisella agents | The Ohio State University Research Foundation (US) | 2010-11-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108823-A1 | ANTI-FRANCISELLA AGENTS | PTGS1, PTGS2, PTGES2 | RXRA 4346/4885RXRB 4387/4885RXRG 4178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.