Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.56 |
| ▸ | RXRB | P28702 | 4/20 | 0.56 |
| ▸ | RXRG | P48443 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 4/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2696125 | 1.00 | RXRA (0.56) | RXRARXRBRXRGS1PR1S1PR5 | |
| SCHEMBL2697875 | 0.89 | ALDH1A1 (0.44) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL2697879 | 0.89 | ALDH1A1 (0.44) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL12685611 | 0.84 | ALDH1A1 (0.48) | ALDH1A1LMNAGAA | |
| SCHEMBL2697721 | 0.82 | RXRA (0.56) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL2697722 | 0.82 | RXRA (0.56) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL2700540 | 0.80 | MAPT (0.50) | RXRARXRBMCL1ALDH1A1LMNA | |
| SCHEMBL2700543 | 0.80 | CYP1A2 (0.54) | RXRARXRBRXRGBCL2L1ALDH1A1 | |
| SCHEMBL2698488 | 0.80 | NR4A1 (0.50) | RXRARXRBRXRGALDH1A1 | |
| SCHEMBL2697768 | 0.80 | MAPT (0.50) | RXRARXRBMCL1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580827-B2 | Anti-Francisella agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-11-12 | — | — | US | disclosed |
| EP-2246332-B1 | Pyrazole derivatives as anti-francisella agents | UNIV OHIO STATE RES FOUND (US) | 2013-09-18 | — | — | EP | disclosed |
| US-20120108823-A1 | ANTI-FRANCISELLA AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-05-03 | — | — | US | disclosed |
| EP-2246332-A1 | Pyrazole derivatives as anti-francisella agents | The Ohio State University Research Foundation (US) | 2010-11-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108823-A1 | ANTI-FRANCISELLA AGENTS | PTGS1, PTGS2, PTGES2 | RXRA 4346/4885RXRB 4387/4885RXRG 4178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.