Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MMP2 | P08253 | 4/20 | 0.58 |
| ▸ | MMP3 | P08254 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.57 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.57 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.56 |
| ▸ | NAAA | Q02083 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 3/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | CASR | P41180 | 1/20 | 0.48 |
| ▸ | TLR2 | O60603 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 5/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2698411 | 1.00 | POLB (0.69) | POLBMEN1KMT2AMMP2MMP3 | |
| SCHEMBL23171829 | 0.88 | POLB (0.54) | POLBMEN1KMT2AMMP2MMP3 | |
| SCHEMBL13814722 | 0.87 | POLB (0.52) | POLBMEN1KMT2AMMP2MMP3 | |
| SCHEMBL18943228 | 0.82 | EPHX2 (0.62) | POLBMEN1KMT2AMMP2MMP3 | |
| SCHEMBL5599660 | 0.80 | MMP2 (0.59) | POLBMEN1KMT2AMMP2MMP3 | |
| SCHEMBL5599303 | 0.80 | MMP2 (0.59) | POLBMEN1KMT2AMMP2MMP3 | |
| SCHEMBL5599307 | 0.80 | MMP2 (0.59) | POLBMEN1KMT2AMMP2MMP3 | |
| SCHEMBL25907902 | 0.80 | POLB (0.60) | POLBMEN1KMT2AALDH1A1CTDSP1 | |
| SCHEMBL10663786 | 0.80 | POLB (0.45) | POLBMMP2MMP3ALDH1A1ASAH1 | |
| SCHEMBL10664841 | 0.80 | POLB (0.45) | POLBMMP2MMP3ALDH1A1ASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160206680-A1 | ANTI-TRYPANOSOME COMPOUNDS AND TREATMENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-07-21 | — | — | US | disclosed |
| US-9321811-B2 | Further novel anti-parasitic compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-04-26 | — | — | US | disclosed |
| US-20140221276-A1 | FURTHER NOVEL ANTI-PARASITIC COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-08-07 | — | — | US | disclosed |
| US-8772247-B2 | Anti-parasitic compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-07-08 | — | — | US | disclosed |
| US-20120108502-A1 | NOVEL ANTI-PARASITIC COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER (US) | 2012-05-03 | — | — | US | disclosed |
| WO-2010108164-A2 | NOVEL ANTI-PARASITIC COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108502-A1 | NOVEL ANTI-PARASITIC COMPOUNDS | NGLY1, PTMS, LRBA | POLB 1840/4885MEN1 3365/4885KMT2A 579/4885 |
| US-20160206680-A1 | ANTI-TRYPANOSOME COMPOUNDS AND TREATMENTS | PDF, TUFM, TRAP1 | POLB 768/4885MEN1 2464/4885KMT2A 1585/4885 |
| US-20140221276-A1 | FURTHER NOVEL ANTI-PARASITIC COMPOUNDS | PTMS, LRBA, PDF | POLB 1914/4885MEN1 3676/4885KMT2A 811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.