Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 18/20 | 0.51 |
| ▸ | THRA | P10827 | 17/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22039129 | 0.87 | THRA (0.67) | THRBTHRA | |
| SCHEMBL25950328 | 0.83 | THRB (0.46) | THRBTHRA | |
| SCHEMBL25949891 | 0.82 | THRB (0.50) | THRBTHRA | |
| SCHEMBL25949862 | 0.79 | THRB (0.44) | THRBTHRA | |
| SCHEMBL25949903 | 0.78 | THRB (0.44) | THRBTHRA | |
| SCHEMBL25926148 | 0.78 | THRB (0.43) | THRBTHRA | |
| SCHEMBL25949905 | 0.77 | THRB (0.45) | THRBTHRAPOLB | |
| SCHEMBL24132121 | 0.76 | THRA (0.74) | THRBTHRA | |
| SCHEMBL24132890 | 0.76 | THRA (0.67) | THRBTHRA | |
| SCHEMBL25949908 | 0.75 | THRB (0.47) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11872207-B2 | Dronedarone and derivatives thereof for treating cancer | MCMASTER UNIVERSITY (CA) | 2024-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11872207-B2 | Dronedarone and derivatives thereof for treating cancer | CYP27A1, CYP3A43, DHCR7 | THRB 3356/4885THRA 3249/4885POLB 2972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.