Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 10/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 10/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21980069 | 0.81 | LMNA (0.38) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL31189173 | 0.79 | TLR9 (0.32) | ALDH1A1HPGDHSD17B10TLR9TLR8 | |
| SCHEMBL26664321 | 0.77 | KDM4E (0.39) | PDE10ARXRAGRIN1GRIN2BALDH1A1 | |
| SCHEMBL27008088 | 0.77 | GRM4 (0.31) | TLR9TLR8TLR7GRM4 | |
| SCHEMBL25151281 | 0.75 | CYP1A2 (0.36) | PDE10AALDH1A1HPGDHSD17B10KCNH2 | |
| SCHEMBL20582351 | 0.74 | ALDH1A1 (0.41) | ALDH1A1HPGDHSD17B10KCNH2 | |
| SCHEMBL27083079 | 0.74 | GAA (0.36) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL25152156 | 0.74 | LMNA (0.39) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL30398185 | 0.74 | LMNA (0.39) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL1826272 | 0.74 | ALDH1A1 (0.41) | ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308576-B1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2025-04-23 | — | — | EP | disclosed |
| EP-4308576-A1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2024-01-24 | — | — | EP | disclosed |
| US-20240018163-A1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-01-18 | — | — | US | disclosed |
| CN-116981674-A | Novel thiazolopyrimidinone derivatives | 豪夫迈·罗氏有限公司 | 2023-10-31 | — | — | CN | disclosed |
| WO-2022194801-A1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2022-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018163-A1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | NDUFS3, FOXM1, MT-ND1 | PDE10A 1536/4885RXRA 1127/4885GRIN1 1040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.