Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL347346 | 1.00 | ALDH1A1 (0.46) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| Bicarbonate SCHEMBL28339996 | 1.00 | ALDH1A1 (0.46) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| Bicarbonate SCHEMBL932354 | 0.97 | POLB (0.43) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| Bicarbonate SCHEMBL10762215 | 0.97 | POLB (0.43) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| Bicarbonate SCHEMBL11351009 | 0.91 | MEN1 (0.48) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| Acetic Acid SCHEMBL10582703 | 0.90 | MEN1 (0.43) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| Carbamic Acid SCHEMBL8746736 | 0.90 | ALDH1A1 (0.43) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| Bicarbonate SCHEMBL22204349 | 0.88 | POLB (0.38) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| SCHEMBL23728834 | 0.86 | TSHR (0.40) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| SCHEMBL37401 | 0.86 | TSHR (0.50) | ALDH1A1TSHRTP53HIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 439 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3559153-B1 | EFFICIENT CURATIVE FOR FREE RADICALLY-CROSSLINKABLE POLYMERS | ARKEMA INC (US) | 2025-07-30 | — | — | EP | claimed |
| US-12098298-B2 | Ultra-fast UV-cured material for repairing surface imperfections | ILLINOIS TOOL WORKS INC. (US) | 2024-09-24 | — | — | US | claimed |
| US-20240198316-A1 | SYNTHETIC POLYMERIC POROUS MEDIUM WITH HIERARCHICAL MULTIPLE LAYER STRUCTURE, ITS DESIGN, SYNTHESIS, MODIFICATION, AND LIQUID CHROMATOGRAPHIC APPLICATIONS | SUZHOU SEPAX TECHNOLOGIES, INC. (CN) | 2024-06-20 | — | — | US | claimed |
| EP-4337357-A1 | SYNTHETIC POLYMERIC POROUS MEDIUM WITH HIERARCHICAL MULTIPLE LAYER STRUCTURE, ITS DESIGN, SYNTHESIS, MODIFICATION, AND LIQUID CHROMATOGRAPHIC APPLICATIONS | Suzhou Sepax Technologies, Inc. (CN) | 2024-03-20 | — | — | EP | claimed |
| CN-117377521-A | Synthetic polymeric porous media with hierarchical multi-layer structure and design, synthesis, modification and liquid chromatography applications thereof | 苏州赛分科技股份有限公司 | 2024-01-09 | — | — | CN | claimed |
| CN-219446359-U | High-strength composite toughened glass | 江苏飞天玻璃实业有限公司 | 2023-08-01 | — | — | CN | claimed |
| CN-115960570-A | Epoxy vinyl type water-based light-cured stone decorative surface adhesive | 武汉市科达云石护理材料有限公司 | 2023-04-14 | — | — | CN | claimed |
| CN-111689859-B | Low-shrinkage resin and preparation method and application thereof | 江苏乾元新材料科技有限公司 | 2023-01-24 | — | — | CN | claimed |
| WO-2022253175-A1 | SYNTHETIC POLYMERIC POROUS MEDIUM WITH HIERARCHICAL MULTIPLE LAYER STRUCTURE, ITS DESIGN, SYNTHESIS, MODIFICATION, AND LIQUID CHROMATOGRAPHIC APPLICATIONS | SUZHOU SEPAX TECHNOLOGIES, INC (CN) | 2022-12-08 | — | — | WO | claimed |
| WO-2022252071-A1 | A SYNTHETIC POLYMERIC POROUS MEDIUM WITH HIERARCHICAL MULTIPLE LAYER STRUCTURE, ITS DESIGN, SYNTHESIS, MODIFICATION, AND LIQUID CHROMATOGRAPHIC APPLICATIONS | SUZHOU SEPAX TECHNOLOGIES, INC (CN) | 2022-12-08 | — | — | WO | claimed |
| US-5531940-A | Method for manufacturing photochromic lenses | INNOTECH, INC. (US) | 1996-07-02 | — | — | US | claimed |
| WO-1995015845-A1 | PHOTOCHROMIC LENSES AND METHOD FOR MANUFACTURING | INNOTECH, INC. (US) | 1995-06-15 | — | — | WO | claimed |
| WO-1994000496-A1 | ACRYLIC/CARBONATE RESIN COMPOSITIONS | EDWARDS BILL R (US) | 1994-01-06 | — | — | WO | claimed |
| US-5250391-A | Photopolymer composition and its use | HUGHES AIRCRAFT COMPANY (US) | 1993-10-05 | — | — | US | claimed |
| WO-1989000704-A1 | RADIATION MONITORING DEVICE | JP LABORATORIES, INC. (US) | 1989-01-26 | — | — | WO | claimed |
| EP-0266233-A1 | Process for polishing organical glass with a polishing composition based on cerium | RHONE-POULENC CHIMIE (FR) | 1988-05-04 | — | — | EP | claimed |
| EP-0065476-B1 | COMPOSITE OF RUBBER AND METAL REINFORCEMENT THEREFOR | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1985-12-11 | — | — | EP | claimed |
| EP-0027550-B1 | HEAT CURABLE MIXTURE OF CASTING RESINS FOR THE PRODUCTION OF SHAPED PLASTIC BODIES WITH OPTICAL SURFACE QUALITY, ITS USE, AND A PROCESS AND DEVICE FOR THE MANUFACTURE OF REAR MIRRORS FOR MOTOR VEHICLES OR THE LIKE | Deutsche Spezialglas AG (DE) | 1985-05-15 | — | — | EP | claimed |
| EP-0065476-A1 | Composite of rubber and metal reinforcement therefor | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1982-11-24 | — | — | EP | claimed |
| US-4022960-A | Polymers with high transparency and refractive index and process for production thereof | AGENCY OF INDUSTRIAL SCIENCE & TECHNOLOGY (JA) | 1977-05-10 | — | — | US | claimed |