Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL10762215 | 1.00 | POLB (0.43) | POLBMEN1KMT2AALDH1A1TSHR | |
| Bicarbonate SCHEMBL347346 | 0.97 | ALDH1A1 (0.46) | POLBMEN1KMT2AALDH1A1TSHR | |
| Bicarbonate SCHEMBL28339996 | 0.97 | ALDH1A1 (0.46) | POLBMEN1KMT2AALDH1A1TSHR | |
| Bicarbonate SCHEMBL270124 | 0.97 | ALDH1A1 (0.46) | POLBMEN1KMT2AALDH1A1TSHR | |
| Bicarbonate SCHEMBL22204349 | 0.91 | POLB (0.38) | POLBMEN1KMT2AALDH1A1TSHR | |
| Bicarbonate SCHEMBL31496491 | 0.89 | MEN1 (0.41) | POLBMEN1KMT2AALDH1A1TSHR | |
| Bicarbonate SCHEMBL11351009 | 0.89 | MEN1 (0.48) | POLBMEN1KMT2AALDH1A1TSHR | |
| Bicarbonate SCHEMBL1206563 | 0.88 | CA1 (0.41) | POLBMEN1KMT2AALDH1A1TSHR | |
| Bicarbonate SCHEMBL11184728 | 0.87 | TSHR (0.43) | POLBMEN1KMT2AALDH1A1TSHR | |
| Carbamic Acid SCHEMBL8746736 | 0.87 | ALDH1A1 (0.43) | POLBMEN1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 227 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1980565-B1 | Oil soluble radiation curable metal-containing compositions | SARTOMER TECHNOLOGY USA LLC (US) | 2011-03-02 | — | — | EP | claimed |
| US-7815496-B2 | Polishing pad of a chemical mechanical polishing apparatus and method of manufacturing the same | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2010-10-19 | — | — | US | claimed |
| EP-1189994-B1 | OIL SOLUBLE RADIATION CURABLE METAL-CONTAINING COMPOUNDS AND COMPOSITIONS | SARTOMER CO INC (US) | 2009-03-18 | — | — | EP | claimed |
| EP-1980565-A1 | Oil soluble radiation curable metal-containing compounds and compositions | SARTOMER COMPANY, INC. (US) | 2008-10-15 | — | — | EP | claimed |
| US-20070197143-A1 | Polishing pad of a chemical mechanical polishing apparatus and method of manufacturing the same | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2007-08-23 | — | — | US | claimed |
| EP-1125965-B1 | Expandable and settable deployable preform containing unsaturated resins, use for casing of wells or canalisation | INST FRANCAIS DU PETROLE (FR) | 2005-04-06 | — | — | EP | claimed |
| JP-2003501541-A | — | — | 2003-01-14 | — | — | JP | claimed |
| US-6399672-B1 | OIL SOLUBLE UNSATURATED COMPOUNDS AND PHOTOINITIATORS | SARTOMER TECHNOLOGIES CO., INC. | 2002-06-04 | — | — | US | claimed |
| EP-1189994-A2 | OIL SOLUBLE RADIATION CURABLE METAL-CONTAINING COMPOUNDS AND COMPOSITIONS | SARTOMER COMPANY, INC. (US) | 2002-03-27 | — | — | EP | claimed |
| US-20010020053-A1 | Expandable and curable flexible preform containing unsaturated resins, for casing a well or a line | INSTITUT FRANCAIS DU PETROLE (FR) | 2001-09-06 | — | — | US | claimed |
| WO-2000075241-A2 | OIL SOLUBLE RADIATION CURABLE METAL-CONTAINING COMPOUNDS AND COMPOSITIONS | SARTOMER COMPANY, INC. (US) | 2000-12-14 | — | — | WO | claimed |
| US-5400175-A | Ultraviolet radiation and blue light blocking polarizing lens | SUNTIGER, INC. (US) | 1995-03-21 | — | — | US | claimed |
| EP-0292475-A4 | ULTRAVIOLET RADIATION AND BLUE LIGHT BLOCKING POLARIZING LENS | — | 1990-09-05 | — | — | EP | claimed |
| EP-0292475-A1 | ULTRAVIOLET RADIATION AND BLUE LIGHT BLOCKING POLARIZING LENS. | JOHANSEN LAURIE A (US) | 1988-11-30 | — | — | EP | claimed |
| EP-0266233-A1 | Process for polishing organical glass with a polishing composition based on cerium | RHONE-POULENC CHIMIE (FR) | 1988-05-04 | — | — | EP | claimed |
| WO-1988002871-A1 | ULTRAVIOLET RADIATION AND BLUE LIGHT BLOCKING POLARIZING LENS | SUNTIGER, INCORPORATED (US) | 1988-04-21 | — | — | WO | claimed |
| US-4073967-A | CURABLE SILANE AND A METAL ALKOXIDE | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1978-02-14 | — | — | US | claimed |
| US-4052520-A | PROCESS FOR COATING A SYNTHETIC POLYMER SHEET MATERIAL WITH A DURABLE ABRASION-RESISTANT VITREOUS COMPOSITION | AMERICAN OPTICAL CORPORATION (US) | 1977-10-04 | — | — | US | claimed |
| US-4042749-A | PROTECTIVE COATINGS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1977-08-16 | — | — | US | claimed |
| US-3991234-A | VACUUM DEPOSITION OF SILICON MONOXIDE AND GLASS | AMERICAN OPTICAL CORPORATION (US) | 1976-11-09 | — | — | US | claimed |