Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL270124 | 1.00 | ALDH1A1 (0.46) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| Bicarbonate SCHEMBL28339996 | 1.00 | ALDH1A1 (0.46) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| Bicarbonate SCHEMBL932354 | 0.97 | POLB (0.43) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| Bicarbonate SCHEMBL10762215 | 0.97 | POLB (0.43) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| Bicarbonate SCHEMBL11351009 | 0.91 | MEN1 (0.48) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| Acetic Acid SCHEMBL10582703 | 0.90 | MEN1 (0.43) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| Carbamic Acid SCHEMBL8746736 | 0.90 | ALDH1A1 (0.43) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| Bicarbonate SCHEMBL22204349 | 0.88 | POLB (0.38) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| SCHEMBL23728834 | 0.86 | TSHR (0.40) | ALDH1A1TSHRTP53HIF1AHSD17B10 | |
| SCHEMBL37401 | 0.86 | TSHR (0.50) | ALDH1A1TSHRTP53HIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 157 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230100363-A1 | MOLECULARLY IMPRINTED POLYMERS FOR EXTRACTION OF CANNABINOIDS AND USES THEREOF | ORCA HOLDINGS, LLC | 2023-03-30 | — | — | US | claimed |
| US-20220177666-A1 | MOLECULARLY IMPRINTED POLYMERS FOR EXTRACTION OF CANNABINOIDS AND USES THEREOF | ORCA HOLDINGS, LLC | 2022-06-09 | — | — | US | claimed |
| CN-112341665-B | Ultraviolet-proof and blue-light-proof optical material and preparation method thereof | 江苏视科新材料股份有限公司 | 2022-06-03 | — | — | CN | claimed |
| EP-3938359-A1 | MOLECULARLY IMPRINTED POLYMERS FOR EXTRACTION OF CANNABINOIDS AND USES THEREOF | 6th Wave Innovations Corp. (US) | 2022-01-19 | — | — | EP | claimed |
| CN-108164627-B | High-transmittance blue-light-proof spectacle lens and preparation method thereof | 江苏全真光学科技股份有限公司 | 2021-04-06 | — | — | CN | claimed |
| CN-112341665-A | Ultraviolet-proof and blue-light-proof optical material and preparation method thereof | 江苏视科新材料股份有限公司 | 2021-02-09 | — | — | CN | claimed |
| WO-2020186077-A1 | MOLECULARLY IMPRINTED POLYMERS FOR EXTRACTION OF CANNABINOIDS AND USES THEREOF | 6th Wave Innovations Corp. (US) | 2020-09-17 | — | — | WO | claimed |
| US-7678870-B2 | Processable molecularly imprinted polymers | THE JOHNS HOPKINS UNIVERSITY (US) | 2010-03-16 | — | — | US | claimed |
| US-20070197746-A1 | Processable molecularly imprinted polymers | THE JOHNS HOPKINS UNIVERSITY | 2007-08-23 | — | — | US | claimed |
| EP-1733211-A4 | PROCESSABLE MOLECULARLY IMPRINTED POLYMERS | UNIV JOHNS HOPKINS (US) | 2007-05-30 | — | — | EP | claimed |
| EP-1733211-A1 | PROCESSABLE MOLECULARLY IMPRINTED POLYMERS | THE JOHNS-HOPKINS UNIVERSITY (US) | 2006-12-20 | — | — | EP | claimed |
| US-20050276781-A1 | Molecularly imprinted phosphate binders for therapeutic use | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2005-12-15 | — | — | US | claimed |
| WO-2005103655-A1 | PROCESSABLE MOLECULARLY IMPRINTED POLYMERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2005-11-03 | — | — | WO | claimed |
| EP-1509302-A1 | SOLID MYCOCTOXIN CARRIERS | Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung (AT) | 2005-03-02 | — | — | EP | claimed |
| WO-2003101580-A1 | SOLID MYCOCTOXIN CARRIERS | Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung (AT) | 2003-12-11 | — | — | WO | claimed |
| US-4460748-A | Process for crosslinking and, if desired, foaming natural or synthetic homo- and/or copolymers | LUPEROX GMBH (DE) | 1984-07-17 | — | — | US | claimed |
| US-20240181430-A1 | POROUS SORPTIVE SOLID PHASE MICROEXTRACTION DEVICES AND PREPARATION THEREOF | MEMORIAL UNIVERSITY OF NEWFOUNDLAND (CA) | 2024-06-06 | — | — | US | disclosed |
| EP-4294559-A1 | POROUS SORPTIVE SOLID PHASE MICROEXTRACTION DEVICES AND PREPARATION THEREOF | Memorial University of Newfoundland (CA) | 2023-12-27 | — | — | EP | disclosed |
| US-4259467-A | Hydrophilic contact lens made from polysiloxanes containing hydrophilic sidechains | BAUSCH & LOMB INCORPORATED (US) | 1981-03-31 | — | — | US | disclosed |
| US-4208506-A | CONTACT LENSES | BAUSCH & LOMB INCORPORATED (US) | 1980-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230100363-A1 | MOLECULARLY IMPRINTED POLYMERS FOR EXTRACTION OF CANNABINOIDS AND USES THEREOF | CNR2, CNR1, CDIPT | ALDH1A1 3487/4885TSHR 4448/4885TP53 4766/4885 |
| US-20220177666-A1 | MOLECULARLY IMPRINTED POLYMERS FOR EXTRACTION OF CANNABINOIDS AND USES THEREOF | CNR2, CNR1, CDIPT | ALDH1A1 3487/4885TSHR 4448/4885TP53 4766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.