Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of Trifluoromethanesulfonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27662424 | 0.86 | TSHR (0.73) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| Trifluoromethanesulfonic Acid SCHEMBL27755078 | 0.86 | TSHR (0.52) | TSHRSMN1; SMN2HTR6ALDH1A1TDP1 | |
| SCHEMBL30671620 | 0.85 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| SCHEMBL3409457 | 0.85 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| SCHEMBL1079321 | 0.85 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| SCHEMBL30307036 | 0.85 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| SCHEMBL30812783 | 0.85 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| SCHEMBL597672 | 0.85 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| Benzene SCHEMBL9751882 | 0.85 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| SCHEMBL2509 | 0.85 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5122612-A | PROCESS FOR PRODUCING 5-AMINO-4-HALOGENO-1H-PYRAZOLE COMPOUNDS | FUJI PHOTO FILM CO., LTD. (JP) | 1992-06-16 | — | — | US | claimed |
| EP-0464736-A1 | A process for producing 5-amino-4-halogeno-1H-pyrazole compounds | Fuji Photo Film Co., Ltd. (JP) | 1992-01-08 | — | — | EP | claimed |
| CN-113754636-B | Quinazoline-containing aza-ether compounds | 湖南化工研究院有限公司 | 2022-10-04 | — | — | CN | disclosed |
| EP-2448917-A2 | METHOD FOR THE ENANTIOSELECTIVE ADDITION OF ORGANOMETALLIC CARBON NUCLEOPHILES TO TRIFLUOROMETHYL KETONES AND USE OF THE METHOD IN THE SYNTHESIS OF HIV REVERSE TRANSCRIPTASE INHIBITORS | Archimica GmbH (DE) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011000532-A2 | METHOD FOR THE ENANTIOSELECTIVE ADDITION OF ORGANOMETALLIC CARBON NUCLEOPHILES TO TRIFLUOROMETHYL KETONES AND USE OF THE METHOD IN THE SYNTHESIS OF HIV REVERSE TRANSCRIPTASE INHIBITORS | ARCHIMICA GMBH (DE) | 2011-01-06 | — | — | WO | disclosed |
| CN-1082672-C | Color filter and method thereof, and liquid crystal panel | CANON KK (JP) | 2002-04-10 | — | — | CN | disclosed |
| CN-1122007-A | Color filter, method of manufacturing IT, and liquid crystal panel | CANON KK (JP) | 1996-05-08 | — | — | CN | disclosed |