Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 9/20 | 0.45 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.34 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2806321 | 0.85 | HIF1A (0.54) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL9817064 | 0.83 | CHRNA7 (0.49) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL9817092 | 0.83 | CHRNA7 (0.49) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL3466381 | 0.82 | CHRNA7 (0.54) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Bromide SCHEMBL2542018 | 0.77 | HIF1A (0.58) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Bromide SCHEMBL79890 | 0.77 | TSHR (0.48) | HIF1ACHRNA7ALDH1A1CYP1A2CYP2D6 | |
| Iodide SCHEMBL1051101 | 0.77 | CHRNA7 (0.55) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| SCHEMBL30663033 | 0.75 | TSHR (0.50) | HIF1ACHRNA7ALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL2446042 | 0.74 | HIF1A (0.74) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Bromide SCHEMBL2449969 | 0.74 | HIF1A (0.74) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188064-B2 | Reducing cell differentiation of adipocyte; reducing body fat | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-05-29 | — | — | US | disclosed |
| EP-1613588-B1 | 2-PROPYLIDENE-19-NOR-VITAMIN D COMPOUNDS | WISCONSIN ALUMNI RES FOUND (US) | 2012-05-09 | — | — | EP | disclosed |
| US-7538098-B2 | 19-nor-vitamin D analogs with 1,2 or 3,2 heterocyclic ring | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-05-26 | — | — | US | disclosed |
| US-7531527-B2 | 2-Propylidene-19-nor-vitamin D compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-05-12 | — | — | US | disclosed |
| WO-2009015180-A2 | NOVEL COMPOUNDS AND METHODS OF USING THEM | SYNDAX PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
| EP-2001860-A2 | 19-NOR-VITAMIN D ANALOGS WITH 1,2,OR 3,2 HETEROCYCLIC RING | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2008026078-A2 | 19-NOR-VITAMIN D ANALOGS WITH 1,2,OR 3,2 HETEROCYCLIC RING | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-03-06 | — | — | WO | disclosed |
| US-20070238712-A1 | 19-Nor-Vitamin D Analogs with 1,2 or 3,2 Heterocyclic Ring | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2007-10-11 | — | — | US | disclosed |
| US-20070213546-A1 | 2-Propylidene-19-nor-vitamin D compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION. (US) | 2007-09-13 | — | — | US | disclosed |
| US-7241747-B2 | 2-propylidene-19-nor-vitamin D compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-07-10 | — | — | US | disclosed |
| US-20060293291-A1 | 2-Propylidene-19-nor-vitamin d compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2006-12-28 | — | — | US | disclosed |
| EP-1613588-A2 | 2-PROPYLIDENE-19-NOR-VITAMIN D COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2006-01-11 | — | — | EP | disclosed |
| US-20050119242-A1 | Vitamin D analogs for obesity prevention and treatment | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2005-06-02 | — | — | US | disclosed |
| US-20040229851-A1 | 2-Propylidene-19-nor-vitamin D compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2004-11-18 | — | — | US | disclosed |
| WO-2004092118-A2 | 2-PROPYLIDENE-19-NOR-VITAMIN D COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2004-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213546-A1 | 2-Propylidene-19-nor-vitamin D compounds | VDR, CD14, CYP24A1 | HIF1A 2894/4885CHRNA7 2856/4885TRAP1 973/4885 |
| US-20060293291-A1 | 2-Propylidene-19-nor-vitamin d compounds | VDR, CD14, CYP24A1 | HIF1A 2894/4885CHRNA7 2856/4885TRAP1 973/4885 |
| US-20070238712-A1 | 19-Nor-Vitamin D Analogs with 1,2 or 3,2 Heterocyclic Ring | CYP24A1, CYP27B1, CYP2R1 | HIF1A 942/4885CHRNA7 3233/4885TRAP1 652/4885 |
| US-20040229851-A1 | 2-Propylidene-19-nor-vitamin D compounds | VDR, CD14, CYP24A1 | HIF1A 2894/4885CHRNA7 2856/4885TRAP1 973/4885 |
| US-20050119242-A1 | Vitamin D analogs for obesity prevention and treatment | VDR, CYP24A1, SCD | HIF1A 576/4885CHRNA7 4094/4885TRAP1 2166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.